Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R1 | P27986 | 5/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1260644 | 1.00 | PIK3R1 (0.49) | PIK3R1PIK3CANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL934754 | 0.93 | NPC1 (0.49) | PIK3R1PIK3CANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28643134 | 0.93 | NPC1 (0.49) | PIK3R1PIK3CANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4412956 | 0.88 | NPC1 (0.48) | PIK3R1PIK3CANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28642662 | 0.88 | NPC1 (0.48) | PIK3R1PIK3CANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL19656225 | 0.85 | PIK3CD (0.54) | PIK3R1PIK3CANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL153714 | 0.85 | PIK3CD (0.54) | PIK3R1PIK3CANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL153713 | 0.85 | PIK3CD (0.54) | PIK3R1PIK3CANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31628325 | 0.85 | PIK3CD (0.54) | PIK3R1PIK3CANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL153834 | 0.84 | NPC1 (0.45) | PIK3R1PIK3CANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220372048-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | INTELLIKINE LLC | 2022-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220372048-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | PIK3CA, AKT3, PIK3C2A | PIK3R1 41/4885PIK3CA 1/4885NPC1 1484/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.