Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 2/20 | 1.00 |
| ▸ | SCN5A | Q14524 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 1/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 1/20 | 1.00 |
| ▸ | DRD3 | P35462 | 1/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | CACNA1F | O60840 | 1/20 | 1.00 |
| ▸ | SCN1A | P35498 | 1/20 | 1.00 |
| ▸ | SCN4A | P35499 | 1/20 | 1.00 |
| ▸ | SCN7A | Q01118 | 1/20 | 1.00 |
| ▸ | CACNA1D | Q01668 | 1/20 | 1.00 |
| ▸ | CACNA1S | Q13698 | 1/20 | 1.00 |
| ▸ | CACNA1C | Q13936 | 1/20 | 1.00 |
| ▸ | SCN9A | Q15858 | 1/20 | 1.00 |
| ▸ | SCN2A | Q99250 | 1/20 | 1.00 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ajmaline SCHEMBL29620363 | 1.00 | CYP2D6 (1.00) | CYP2D6KCNH2SCN5AKMT2AADRA2B | |
| Ajmaline SCHEMBL30892623 | 1.00 | CYP2D6 (1.00) | CYP2D6KCNH2SCN5AKMT2AADRA2B | |
| Ajmaline SCHEMBL29811209 | 1.00 | CYP2D6 (1.00) | CYP2D6KCNH2SCN5AKMT2AADRA2B | |
| Ajmaline SCHEMBL14029381 | 1.00 | CYP2D6 (1.00) | CYP2D6KCNH2SCN5AKMT2AADRA2B | |
| Ajmaline SCHEMBL2787287 | 1.00 | CYP2D6 (1.00) | CYP2D6KCNH2SCN5AKMT2AADRA2B | |
| Ajmaline SCHEMBL23295973 | 1.00 | CYP2D6 (1.00) | CYP2D6KCNH2SCN5AKMT2AADRA2B | |
| Ajmaline SCHEMBL10422895 | 1.00 | CYP2D6 (1.00) | CYP2D6KCNH2SCN5AKMT2AADRA2B | |
| Ajmaline SCHEMBL29354066 | 1.00 | CYP2D6 (1.00) | CYP2D6KCNH2SCN5AKMT2AADRA2B | |
| Ajmaline SCHEMBL15384531 | 1.00 | CYP2D6 (1.00) | CYP2D6KCNH2SCN5AKMT2AADRA2B | |
| Ajmaline SCHEMBL18950 | 1.00 | CYP2D6 (1.00) | CYP2D6KCNH2SCN5AKMT2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3370539-B1 | ADSORPTION SYSTEM AND METHOD FOR OPERATING AN ADSORPTION SYSTEM | FLAVOLOGIC GMBH (DE) | 2025-07-02 | — | — | EP | disclosed |
| CN-118903120-A | Combination of beta-lactam compound and probenecid and use thereof | 伊泰伦治疗国际有限公司 | 2024-11-08 | — | — | CN | disclosed |
| US-12109197-B2 | Combinations of β-lactam compounds and probenecid and uses thereof | Iterum Therapeutics International Limited (IE) | 2024-10-08 | — | — | US | disclosed |
| CN-117597327-A | Pharmaceutical preparation | 第一波动生物制药股份有限公司 | 2024-02-23 | — | — | CN | disclosed |
| US-20230218588-A1 | COMBINATIONS OF BETA-LACTAM COMPOUNDS AND PROBENECID AND USES THEREOF | Iterum Therapeutics International Limited (IE) | 2023-07-13 | — | — | US | disclosed |
| EP-2938328-B1 | MONOLITHIC PHARMACEUTICAL FORM FOR MODIFIED RELEASE OF AN ACTIVE INGREDIENT COMBINATION | HENNIG ARZNEIMITTEL GMBH&CO KG (DE) | 2023-07-05 | — | — | EP | disclosed |
| US-11554112-B2 | Combinations of β-lactam compounds and probenecid and uses thereof | Herum Therapeutics International Limited (IE) | 2023-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11554112-B2 | Combinations of β-lactam compounds and probenecid and uses thereof | PEPD, BTD, NRDC | CYP2D6 562/4885KCNH2 2687/4885SCN5A 1266/4885 |
| US-12109197-B2 | Combinations of β-lactam compounds and probenecid and uses thereof | PEPD, BTD, NRDC | CYP2D6 562/4885KCNH2 2687/4885SCN5A 1266/4885 |
| US-20230218588-A1 | COMBINATIONS OF BETA-LACTAM COMPOUNDS AND PROBENECID AND USES THEREOF | PEPD, NRDC, BTD | CYP2D6 582/4885KCNH2 2524/4885SCN5A 1186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.