SCHEMBL30117293

SCHEMBL30117293

COc1cc2ncnc(-c3ccc(NCCNS(=O)(=O)NC(=O)OC(C)(C)C)nc3)c2cc1OC

nearest known ligand 0.69

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ENPP1 P22413 7/20 0.69
KIT P10721 7/20 0.44
PDE10A Q9Y233 4/20 0.40
CA12 O43570 1/20 0.36
CA1 P00915 1/20 0.36
CA7 P43166 1/20 0.36
CA14 Q9ULX7 1/20 0.36
ATM Q13315 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23762390 1.00 ENPP1 (0.69) ENPP1KITPDE10ACA12CA1
SCHEMBL25656210 0.90 ENPP1 (0.54) ENPP1KITCA12CA1CA7
SCHEMBL23726281 0.89 ENPP1 (0.75) ENPP1KITPDE10A
SCHEMBL23762330 0.85 ENPP1 (0.70) ENPP1KITPDE10ACA12CA1
SCHEMBL30117280 0.85 ENPP1 (0.70) ENPP1KITPDE10ACA12CA1
SCHEMBL23727079 0.83 ENPP1 (0.77) ENPP1KITPDE10A
SCHEMBL23762391 0.82 ENPP1 (1.00) ENPP1KIT
Hydrochloric Acid SCHEMBL30117275 0.81 ENPP1 (0.98) ENPP1KIT
Hydrochloric Acid SCHEMBL23726792 0.81 ENPP1 (0.98) ENPP1KIT
Hydrochloric Acid SCHEMBL23726791 0.78 ENPP1 (0.71) ENPP1KITPDE10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4100394-B1 INHIBITORS OF ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) AND METHODS OF USE THEREOF STINGRAY THERAPEUTICS INC (US) 2026-04-08 EP disclosed
US-20250092018-A1 INHIBITORS OF ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) AND METHODS OF USE THEREOF STINGRAY THERAPEUTICS INC (US) 2025-03-20 US disclosed
US-12152015-B2 Inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) and methods of use thereof Stingray Therapeutics, Inc. (US) 2024-11-26 US disclosed
US-20230183212-A1 INHIBITORS OF ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) AND METHODS OF USE THEREOF STINGRAY THERAPEUTICS INC (US) 2023-06-15 US disclosed
US-11591313-B2 Inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) and methods of use thereof Stingray Therapeutics, Inc. (US) 2023-02-28 US disclosed
EP-4100394-A1 INHIBITORS OF ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) AND METHODS OF USE THEREOF Stingray Therapeutics, Inc. (US) 2022-12-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230183212-A1 INHIBITORS OF ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) AND METHODS OF USE THEREOF ENPP1, ENPP3, PPA1 ENPP1 1/4885KIT 4739/4885PDE10A 250/4885
US-11591313-B2 Inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) and methods of use thereof ENPP1, ENPP3, PPA1 ENPP1 1/4885KIT 4739/4885PDE10A 250/4885
US-20250092018-A1 INHIBITORS OF ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) AND METHODS OF USE THEREOF ENPP1, ENPP3, PDE7A ENPP1 1/4885KIT 4741/4885PDE10A 207/4885
US-12152015-B2 Inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) and methods of use thereof ENPP1, ENPP3, PPA1 ENPP1 1/4885KIT 4739/4885PDE10A 250/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.