Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 13/20 | 0.64 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.52 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.52 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15638831 | 1.00 | TGFBR1 (0.64) | TGFBR1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL30117385 | 0.95 | TGFBR1 (0.58) | TGFBR1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL15638331 | 0.95 | TGFBR1 (0.58) | TGFBR1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL15638195 | 0.93 | TGFBR1 (0.54) | TGFBR1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL30117415 | 0.93 | TGFBR1 (0.54) | TGFBR1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL15638180 | 0.92 | TGFBR1 (0.53) | TGFBR1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL30117510 | 0.88 | TGFBR1 (0.51) | TGFBR1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL15638561 | 0.88 | TGFBR1 (0.51) | TGFBR1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL15639482 | 0.88 | TGFBR1 (0.51) | TGFBR1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL15638219 | 0.87 | TGFBR1 (0.49) | TGFBR1PIK3CDPIK3R1PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903978-B1 | GDF-8 INHIBITORS | RIGEL PHARMACEUTICALS INC (US) | 2022-12-07 | — | — | EP | claimed |