Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 11/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.40 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15639501 | 1.00 | TGFBR1 (0.44) | TGFBR1MAPK14ADORA2AADORA2BADORA1 | |
| SCHEMBL15638144 | 0.83 | TGFBR1 (0.59) | TGFBR1TGFBR2 | |
| SCHEMBL15638030 | 0.83 | TGFBR1 (0.53) | TGFBR1MAPK14TGFBR2 | |
| SCHEMBL15639173 | 0.83 | TGFBR1 (0.48) | TGFBR1MAPK14ADORA2AADORA2BADORA1 | |
| SCHEMBL15638552 | 0.82 | TGFBR1 (0.52) | TGFBR1MAPK14TGFBR2KMO | |
| SCHEMBL19654934 | 0.82 | MAPK14 (0.40) | TGFBR1MAPK14ADORA2AADORA2BADORA1 | |
| SCHEMBL15639931 | 0.79 | TGFBR1 (0.40) | TGFBR1TGFBR2KMOGRIN2B | |
| SCHEMBL15639320 | 0.79 | TGFBR1 (0.53) | TGFBR1TGFBR2 | |
| SCHEMBL15639413 | 0.79 | TGFBR1 (0.47) | TGFBR1MAPK14ADORA2AADORA1TGFBR2 | |
| SCHEMBL30117480 | 0.79 | TGFBR1 (0.47) | TGFBR1MAPK14ADORA2AADORA1TGFBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903978-B1 | GDF-8 INHIBITORS | RIGEL PHARMACEUTICALS INC (US) | 2022-12-07 | — | — | EP | claimed |