Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | METAP2 | P50579 | 2/20 | 0.47 |
| ▸ | METAP1 | P53582 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4381780 | 0.98 | MAPT (0.49) | MAPTLMNAMETAP2METAP1HDAC6 | |
| Butane SCHEMBL3022746 | 0.93 | MAPT (0.48) | MAPTLMNAMETAP2METAP1HDAC6 | |
| SCHEMBL3011820 | 0.84 | MAPT (0.46) | MAPTLMNAMETAP2METAP1HDAC6 | |
| SCHEMBL28128326 | 0.83 | MAPT (0.51) | MAPTLMNAMETAP2METAP1HDAC6 | |
| SCHEMBL721177 | 0.80 | MAPT (0.48) | MAPTLMNAMETAP2METAP1HDAC6 | |
| SCHEMBL4461219 | 0.76 | SRC (0.57) | MAPTLMNAMETAP2METAP1HDAC6 | |
| SCHEMBL4381777 | 0.76 | LMNA (0.50) | MAPTLMNAMETAP2METAP1HDAC6 | |
| SCHEMBL7261599 | 0.76 | MAPT (0.54) | MAPTLMNAMETAP2METAP1HDAC6 | |
| SCHEMBL24179773 | 0.74 | LMNA (0.55) | MAPTLMNAMETAP2METAP1HDAC6 | |
| SCHEMBL4381775 | 0.74 | MAPT (0.58) | MAPTLMNAMETAP2METAP1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2522394-B1 | Substituted phosphonates and their use decreasing amyloid aggregates | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2016-12-28 | — | — | EP | disclosed |
| US-8513219-B2 | Substituted phosphonates and their use in decreasing amyloid aggregates | QUEEN MARY & WESTFIELD COLLEGE, UNIVERSITY OF LONDON (GB) | 2013-08-20 | — | — | US | disclosed |
| EP-2522394-A2 | Substituted phosphonates and their use decreasing amyloid aggregates | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2012-11-14 | — | — | EP | disclosed |
| US-20100204183-A1 | Substituted Phosphonates and Their Use In Decreasing Amyloid Aggregates | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2010-08-12 | — | — | US | disclosed |
| EP-2152368-A1 | SUBSTITUTED PHOSPHONATES AND THEIR USE IN DECREASING AMYLOID AGGREGATES | Queen Mary and Westfield College (GB) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008135743-A1 | SUBSTITUTED PHOSPHONATES AND THEIR USE IN DECREASING AMYLOID AGGREGATES | QUEEN MARY AND WESTFIELD COLLEGE (GB) | 2008-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204183-A1 | Substituted Phosphonates and Their Use In Decreasing Amyloid Aggregates | PSEN2, PSEN1, APP | MAPT 4/4885LMNA 3114/4885METAP2 881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.