Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.52 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 6/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 6/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.38 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.38 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29744751 | 0.90 | PDK4 (0.54) | NR1H2PDK4GRM5GRM1HTR6 | |
| SCHEMBL6402391 | 0.90 | PDK4 (0.54) | NR1H2PDK4GRM5GRM1HTR6 | |
| Bicarbonate SCHEMBL29947017 | 0.86 | PDK4 (0.51) | NR1H2PDK4GRM5GRM1HTR6 | |
| SCHEMBL30822385 | 0.81 | PDK4 (0.54) | NR1H2PDK4GRM5GRM1HTR6 | |
| SCHEMBL27208421 | 0.81 | PDK4 (0.54) | NR1H2PDK4GRM5GRM1HTR6 | |
| SCHEMBL20046146 | 0.80 | GPR119 (0.43) | NR1H2PDK4GPR119DPP4 | |
| SCHEMBL13993111 | 0.78 | GRM1 (0.57) | PDK4GRM5GRM1HTR6JAK1 | |
| SCHEMBL22957463 | 0.78 | PDK4 (0.51) | NR1H2PDK4GRM5GRM1HTR6 | |
| SCHEMBL1240331 | 0.77 | GRM5 (0.53) | PDK4GRM5GRM1ESR2 | |
| SCHEMBL24310174 | 0.77 | PDK4 (0.55) | PDK4GRM5GRM1ESR2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4351583-A1 | THERAPEUTICS FOR THE DEGRADATION OF MUTANT BRAF | C4 Therapeutics, Inc. (US) | 2024-04-17 | — | — | EP | disclosed |
| WO-2022261250-A1 | THERAPEUTICS FOR THE DEGRADATION OF MUTANT BRAF | C4 THERAPEUTICS, INC. (US) | 2022-12-15 | — | — | WO | disclosed |