SCHEMBL30122046

SCHEMBL30122046

CC(C)(O)c1ccc2c(c1)C(=O)N(Cc1ccc(Cl)cc1)C2c1ccc(Cl)cc1

nearest known ligand 0.48

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MDM2 Q00987 20/20 0.48
TP53 P04637 12/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30122200 0.90 MDM2 (0.45) MDM2TP53
SCHEMBL30122078 0.87 MDM2 (0.47) MDM2TP53
SCHEMBL17366165 0.82 MDM2 (0.55) MDM2TP53
SCHEMBL30122321 0.79 MDM2 (0.46) MDM2TP53
SCHEMBL30121977 0.75 MDM2 (0.64) MDM2TP53
SCHEMBL30122066 0.74 MDM2 (0.41) MDM2TP53
SCHEMBL31472265 0.74 CCR1 (0.43) MDM2TP53
SCHEMBL17366164 0.73 MDM2 (0.53) MDM2TP53
SCHEMBL17366166 0.73 MDM2 (0.58) MDM2TP53
SCHEMBL17366174 0.73 MDM2 (0.58) MDM2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115572252-A Isoindolinone inhibitors of MDM2-P53 interaction with anti-cancer activity 阿斯泰克斯治疗有限公司 2023-01-06 CN disclosed