Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 6/20 | 0.43 |
| ▸ | CDK2 | P24941 | 6/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.34 |
| ▸ | SYK | P43405 | 4/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.32 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3012272 | 1.00 | CCNE1 (0.43) | CCNE1CDK2FLT3IRAK4SYK | |
| SCHEMBL3526106 | 0.89 | CCNE1 (0.39) | CCNE1CDK2FLT3IRAK4SYK | |
| SCHEMBL3526110 | 0.88 | CCNE1 (0.37) | CCNE1CDK2FLT3IRAK4SYK | |
| SCHEMBL3012863 | 0.84 | ALDH1A1 (0.36) | SYKRIPK1KCNQ3KCNQ2AURKA | |
| SCHEMBL3023237 | 0.77 | CCNE1 (0.54) | CCNE1CDK2FLT3IRAK4SYK | |
| SCHEMBL3023241 | 0.77 | CCNE1 (0.54) | CCNE1CDK2FLT3IRAK4SYK | |
| SCHEMBL4760303 | 0.76 | CCNE1 (0.56) | CCNE1CDK2FLT3IRAK4SYK | |
| SCHEMBL3013076 | 0.76 | CCNE1 (0.58) | CCNE1CDK2FLT3IRAK4SYK | |
| SCHEMBL3013081 | 0.76 | CCNE1 (0.58) | CCNE1CDK2FLT3IRAK4SYK | |
| SCHEMBL3021425 | 0.73 | CCNE1 (0.52) | CCNE1CDK2FLT3RIPK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928879-B1 | FUSED HETEROCYCLIC COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2013-02-13 | — | — | EP | disclosed |
| US-20100204212-A1 | FUSED HETEROCYCLIC COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL-MYERS SQUIBB COMPANY | 2010-08-12 | — | — | US | disclosed |
| US-20070078136-A1 | Fused heterocyclic compounds useful as kinase modulators | BRISTOL-MYERS SQUIBB COMPANY | 2007-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078136-A1 | Fused heterocyclic compounds useful as kinase modulators | MAP3K2, MAP3K3, MAP4K2 | CCNE1 598/4885CDK2 50/4885FLT3 155/4885 |
| US-20100204212-A1 | FUSED HETEROCYCLIC COMPOUNDS USEFUL AS KINASE MODULATORS | MAP2K2, MAP3K2, MAP4K2 | CCNE1 468/4885CDK2 40/4885FLT3 345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.