Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.54 |
| ▸ | PDE5A | O76074 | 5/20 | 0.54 |
| ▸ | HTR3A | P46098 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23723290 | 1.00 | HRH4 (0.54) | HRH4PDE5AHTR3ASLC6A3KDM4E | |
| SCHEMBL23747916 | 0.87 | HRH4 (0.59) | HRH4PDE5AHTR3AKDM4EKMT2A | |
| SCHEMBL23723346 | 0.84 | PDE5A (0.48) | HRH4PDE5AHTR3ASLC6A3KDM4E | |
| SCHEMBL30125141 | 0.84 | PDE5A (0.48) | HRH4PDE5AHTR3ASLC6A3KDM4E | |
| SCHEMBL23747915 | 0.79 | CYP1A2 (0.57) | SLC6A3KDM4EKMT2AHSD17B10MAPT | |
| SCHEMBL23747961 | 0.79 | HRH4 (0.63) | HRH4PDE5AHTR3AKDM4EHSD17B10 | |
| SCHEMBL23747842 | 0.78 | GBA1 (0.55) | PDE5ASLC6A3KDM4EKMT2AMAPT | |
| SCHEMBL23747909 | 0.78 | PDE5A (0.54) | HRH4PDE5ASLC6A3KMT2AMAPT | |
| SCHEMBL23747914 | 0.78 | SLC6A3 (0.54) | HRH4PDE5ASLC6A3HSD17B10ALOX15 | |
| SCHEMBL23723287 | 0.78 | SLC6A3 (0.54) | HRH4PDE5ASLC6A3ACP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100395-A1 | QUINAZOLINE COMPOUNDS AND THE USE THEREOF IN THE TREATMENT OF CANCER | Trobio Therapeutics Pty Ltd (AU) | 2022-12-14 | — | — | EP | disclosed |