Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.45 |
| ▸ | AR | P10275 | 5/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | F13A1 | P00488 | 1/20 | 0.39 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
| ▸ | TGM1 | P22735 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30635739 | 0.85 | HSD11B1 (0.46) | RETARHSD11B1GPR119NR1H2 | |
| SCHEMBL30411472 | 0.85 | HSD11B1 (0.46) | RETARHSD11B1GPR119NR1H2 | |
| SCHEMBL30126126 | 0.84 | RET (0.47) | RETARHSD11B1GPR119NR1H2 | |
| SCHEMBL30411352 | 0.83 | HSD11B1 (0.45) | RETARHSD11B1GPR119PARP1 | |
| SCHEMBL30635735 | 0.83 | F13A1 (0.45) | RETARHSD11B1GPR119PARP1 | |
| SCHEMBL30411911 | 0.83 | F13A1 (0.45) | RETARHSD11B1GPR119PARP1 | |
| SCHEMBL30906308 | 0.82 | RET (0.46) | RETARHSD11B1GPR119NR1H2 | |
| SCHEMBL11920568 | 0.82 | HSD11B1 (0.43) | RETHSD11B1GPR119PARP1F13A1 | |
| Bicarbonate SCHEMBL30412048 | 0.81 | HSD11B1 (0.43) | RETARHSD11B1GPR119PARP1 | |
| SCHEMBL31126232 | 0.80 | AR (0.66) | RETARCCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022266458-A1 | 6-HETEROCYCLOALKYL-QUINAZOLINE DERIVATIVES AND USES THEREOF | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2022-12-22 | — | — | WO | disclosed |