Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 3/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.35 |
| ▸ | PGK1 | P00558 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30126525 | 0.90 | JAK3 (0.44) | JAK3RETMAP4K4EPHA2KDR | |
| SCHEMBL30126746 | 0.88 | JAK3 (0.44) | JAK3RETMAP4K4CNR1CNR2 | |
| SCHEMBL31257369 | 0.84 | TLR9 (0.49) | MAP4K4EPHA2KDREPHB4TLR9 | |
| Hydrochloric Acid SCHEMBL31257542 | 0.83 | TLR9 (0.48) | MAP4K4EPHA2KDREPHB4TLR9 | |
| SCHEMBL30126115 | 0.81 | JAK3 (0.42) | JAK3RETMAP4K4CNR1CNR2 | |
| SCHEMBL30127598 | 0.78 | JAK3 (0.45) | JAK3RETMAP4K4TLR9CNR1 | |
| SCHEMBL30126244 | 0.76 | RET (0.44) | JAK3RETMAP4K4 | |
| SCHEMBL30127295 | 0.75 | EGFR (0.49) | KDR | |
| SCHEMBL30127328 | 0.75 | MAP4K4 (0.52) | JAK3RETMAP4K4 | |
| SCHEMBL31257323 | 0.73 | TLR9 (0.52) | MAP4K4EPHA2KDREPHB4TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022266458-A1 | 6-HETEROCYCLOALKYL-QUINAZOLINE DERIVATIVES AND USES THEREOF | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2022-12-22 | — | — | WO | disclosed |