Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 7/20 | 0.44 |
| ▸ | JAK3 | P52333 | 3/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | ADK | P55263 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 2/20 | 0.33 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30125727 | 0.89 | RET (0.45) | RETJAK3MAP4K4GPR119CYP11B2 | |
| SCHEMBL30126115 | 0.81 | JAK3 (0.42) | RETJAK3MAP4K4GPR119 | |
| SCHEMBL30126501 | 0.81 | EGFR (0.47) | RETADK | |
| SCHEMBL30126479 | 0.80 | ERBB2 (0.39) | RETJAK3 | |
| SCHEMBL31713482 | 0.79 | RET (0.52) | RETJAK3GPR119ADKEIF2AK4 | |
| SCHEMBL30126746 | 0.77 | JAK3 (0.44) | RETJAK3MAP4K4GPR119PIK3CD | |
| SCHEMBL22638913 | 0.76 | GPR119 (0.59) | RETJAK3GPR119 | |
| SCHEMBL31401450 | 0.76 | RET (0.46) | RETJAK3GPR119CYP11B2CRBN | |
| SCHEMBL30126087 | 0.76 | JAK3 (0.43) | RETJAK3MAP4K4 | |
| SCHEMBL31713536 | 0.75 | JAK3 (0.44) | RETJAK3GPR119EIF2AK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022266458-A1 | 6-HETEROCYCLOALKYL-QUINAZOLINE DERIVATIVES AND USES THEREOF | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2022-12-22 | — | — | WO | disclosed |