Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | BTK | Q06187 | 2/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.46 |
| ▸ | TEC | P42680 | 1/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.46 |
| ▸ | EPHA4 | P54764 | 1/20 | 0.46 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.46 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30125755 | 1.00 | EGFR (0.48) | EGFRERBB2KCNH2BTKRIPK2 | |
| SCHEMBL30125765 | 0.96 | EGFR (0.51) | EGFRERBB2KCNH2BTKRIPK2 | |
| SCHEMBL30126357 | 0.96 | EGFR (0.51) | EGFRERBB2KCNH2BTKRIPK2 | |
| SCHEMBL30125786 | 0.86 | PIK3CD (0.48) | EGFRERBB2EPHB4 | |
| SCHEMBL30127558 | 0.86 | PIK3CD (0.48) | EGFRERBB2EPHB4 | |
| SCHEMBL30126934 | 0.86 | PIK3CD (0.48) | EGFRERBB2EPHB4 | |
| SCHEMBL30125952 | 0.86 | PIK3CD (0.48) | EGFRERBB2EPHB4 | |
| SCHEMBL30125958 | 0.86 | EGFR (0.49) | EGFRERBB2FGFR4 | |
| SCHEMBL30127058 | 0.82 | EGFR (0.49) | EGFRERBB2BTKFGFR4 | |
| SCHEMBL30126517 | 0.82 | PIK3CD (0.51) | EGFRERBB2EPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022266458-A1 | 6-HETEROCYCLOALKYL-QUINAZOLINE DERIVATIVES AND USES THEREOF | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2022-12-22 | — | — | WO | disclosed |