Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 10/20 | 0.48 |
| ▸ | PDE1B | Q01064 | 10/20 | 0.48 |
| ▸ | PDE1C | Q14123 | 10/20 | 0.48 |
| ▸ | PDE2A | O00408 | 5/20 | 0.48 |
| ▸ | PDE5A | O76074 | 3/20 | 0.48 |
| ▸ | CFTR | P13569 | 2/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SCN1A | P35498 | 1/20 | 0.48 |
| ▸ | PDE6C | P51160 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.48 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11175917 | 0.84 | PDE1A (0.35) | PDE1APDE1BPDE1CPDE2APDE5A | |
| SCHEMBL11193540 | 0.83 | PDE4A (0.44) | TSHRPDE4AMAPK1PDE4BPDE4C | |
| SCHEMBL4430296 | 0.77 | PDE3B (0.39) | ADORA1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11178750 | 0.74 | HTT (0.35) | TSHRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11175925 | 0.72 | PDE4A (0.34) | TSHRPDE4AMAPK1PDE4BPDE4C | |
| SCHEMBL3070917 | 0.72 | PARG (0.45) | PDE1APDE1BPDE1CMAPK1LMNA | |
| SCHEMBL10992924 | 0.72 | PDE1A (0.46) | PDE1APDE1BPDE1CPDE2APDE5A | |
| SCHEMBL2456557 | 0.71 | PDE1A (0.53) | PDE1APDE1BPDE1CPDE2APDE5A | |
| SCHEMBL5410997 | 0.71 | PDE1A (0.55) | PDE1APDE1BPDE1CPDE2APDE5A | |
| Isobutylmethylxanthine SCHEMBL1020643 | 0.71 | PDE2A (0.62) | PDE1APDE1BPDE1CPDE2APDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0077372-A1 | NEW DERIVATIVES OF PYRAZOLO(3,4-d)PYRIMIDINE, PREPARATION METHOD THEREOF AND REMEDY CONTAINING THEM | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1983-04-27 | — | — | EP | claimed |
| WO-1982003626-A1 | NEW DERIVATIVES OF PYRAZOLO(3,4-D)PYRIMIDINE,PREPARATION METHOD THEREOF AND REMEDY CONTAINING THEM | GAURI KAILASH KUMAR | 1982-10-28 | — | — | WO | claimed |
| EP-0063381-A1 | Pyrazolo(3-4-d) pyrimidines, process for their preparation and pharmaceutical compositions containing them | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1982-10-27 | — | — | EP | claimed |
| EP-2023729-B1 | ORGANIC COMPOUNDS | INTRA CELLULAR THERAPIES INC (US) | 2016-05-04 | — | — | EP | disclosed |
| US-9255099-B2 | Pyrazolo[3,4-D]pyrimidine-4,6(5H,7H)-diones as phosphodiesterase 1 inhibitors | INTRA-CELLULAR THERAPIES, INC. (US) | 2016-02-09 | — | — | US | disclosed |
| US-20100173878-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. (US) | 2010-07-08 | — | — | US | disclosed |
| EP-2023729-A2 | ORGANIC COMPOUNDS | Intra-Cellular Therapies, Inc. (US) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007143705-A2 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. (US) | 2007-12-13 | — | — | WO | disclosed |
| EP-0975636-B1 | 1H-PYRAZOLO[3,4-D]PYRIMIDINE-4,6-DIONES AS T-CELL PROLIFERATION INHIBITORS | ASTRAZENECA AB (SE) | 2003-07-23 | — | — | EP | disclosed |
| US-6028074-A | FOR TREATING ALLOGRAFT REJECTION | ASTRA PHARMACEUTICALS, LTD. (GB) | 2000-02-22 | — | — | US | disclosed |
| EP-0975636-A1 | NOVEL COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998046606-A1 | NOVEL COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-10-22 | — | — | WO | disclosed |
| US-4511557-A | CALF'S BLOOD DIAYSATE AS VASODILATION POTENTIATOR | GAURI KAILASH KUMAR (DE) | 1985-04-16 | — | — | US | disclosed |
| EP-0106309-A2 | Biologically active extracts, process for their manufacture, medicinal and cosmetical preparations comprising them, and their use as additives in foodstuffs and stimulants | Gauri, Kailash Kumar, Dr. Prof. (DE) | 1984-04-25 | — | — | EP | disclosed |
| EP-0077372-A1 | NEW DERIVATIVES OF PYRAZOLO(3,4-d)PYRIMIDINE, PREPARATION METHOD THEREOF AND REMEDY CONTAINING THEM | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1983-04-27 | — | — | EP | disclosed |
| WO-1982003626-A1 | NEW DERIVATIVES OF PYRAZOLO(3,4-D)PYRIMIDINE,PREPARATION METHOD THEREOF AND REMEDY CONTAINING THEM | GAURI KAILASH KUMAR | 1982-10-28 | — | — | WO | disclosed |
| EP-0063381-A1 | Pyrazolo(3-4-d) pyrimidines, process for their preparation and pharmaceutical compositions containing them | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1982-10-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173878-A1 | ORGANIC COMPOUNDS | PDE3A, PDE7A, PDE3B | PDE1A 15/4885PDE1B 17/4885PDE1C 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.