Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 2/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.38 |
| ▸ | GPR3 | P46089 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ANPEP | P15144 | 1/20 | 0.30 |
| ▸ | LAP3 | P28838 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24876794 | 1.00 | LPL (0.38) | LPLLIPGGPR3KDM4ECYP2A6 | |
| SCHEMBL15159260 | 0.77 | MEN1 (0.37) | LPLLIPGKDM4ECYP1A2MEN1 | |
| SCHEMBL732170 | 0.76 | LPL (0.47) | LPLLIPGKDM4ECYP2A6CYP1A2 | |
| SCHEMBL774348 | 0.76 | CYP1A2 (0.46) | LPLLIPGKDM4ECYP2A6CYP1A2 | |
| SCHEMBL30149369 | 0.76 | CYP1A2 (0.46) | LPLLIPGKDM4ECYP2A6CYP1A2 | |
| SCHEMBL2018549 | 0.73 | LPL (0.50) | LPLLIPGANPEPLAP3 | |
| SCHEMBL20829045 | 0.72 | LPL (0.44) | LPLLIPGKDM4ECYP2A6CYP1A2 | |
| SCHEMBL21446903 | 0.72 | LPL (0.44) | LPLLIPGKDM4ECYP2A6CYP1A2 | |
| SCHEMBL30271873 | 0.72 | LPL (0.44) | LPLLIPGKDM4ECYP2A6CYP1A2 | |
| SCHEMBL21446902 | 0.72 | LPL (0.48) | LPLLIPGANPEPLAP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4367117-A1 | TRICYCLIC COMPOUNDS AS INHIBITORS OF KRAS | Incyte Corporation (US) | 2024-05-15 | — | — | EP | disclosed |
| WO-2023283213-A1 | TRICYCLIC COMPOUNDS AS INHIBITORS OF KRAS | INCYTE CORPORATION (US) | 2023-01-12 | — | — | WO | disclosed |