Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.34 |
| ▸ | HTR2C | P28335 | 4/20 | 0.34 |
| ▸ | HTR2B | P41595 | 4/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24876118 | 1.00 | HTR2A (0.34) | HTR2AHTR2CHTR2BGPR84USP2 | |
| SCHEMBL24876410 | 0.77 | MAPK13 (0.32) | — | |
| SCHEMBL30129971 | 0.77 | MAPK13 (0.32) | — | |
| SCHEMBL534206 | 0.75 | LPL (0.39) | — | |
| SCHEMBL30821196 | 0.75 | LPL (0.39) | — | |
| SCHEMBL31436730 | 0.74 | JAK2 (0.36) | — | |
| SCHEMBL23210795 | 0.74 | JAK2 (0.36) | — | |
| SCHEMBL1856232 | 0.74 | CMA1 (0.45) | HTR2AHTR2CHTR2BGPR84IMPDH2 | |
| SCHEMBL19100562 | 0.73 | JAK2 (0.39) | HTR2AHTR2CHTR2B | |
| SCHEMBL25066353 | 0.73 | HTR2A (0.38) | HTR2AHTR2CHTR2BGPR84IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4367117-A1 | TRICYCLIC COMPOUNDS AS INHIBITORS OF KRAS | Incyte Corporation (US) | 2024-05-15 | — | — | EP | disclosed |
| WO-2023283213-A1 | TRICYCLIC COMPOUNDS AS INHIBITORS OF KRAS | INCYTE CORPORATION (US) | 2023-01-12 | — | — | WO | disclosed |