Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pravastatin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR known ✓ | P04035 | 10/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | SLCO1B1 | Q9Y6L6 | 3/20 | 0.84 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.84 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.84 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.69 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pravastatin SCHEMBL27522597 | 1.00 | HMGCR (1.00) | HMGCRALOX15SLCO1B1SLC22A8SLCO1B3 | |
| Pravastatin SCHEMBL3014 | 1.00 | HMGCR (1.00) | HMGCRALOX15SLCO1B1SLC22A8SLCO1B3 | |
| Pravastatin SCHEMBL5598406 | 1.00 | HMGCR (1.00) | HMGCRALOX15SLCO1B1SLC22A8SLCO1B3 | |
| Pravastatin SCHEMBL14472019 | 1.00 | HMGCR (1.00) | HMGCRALOX15SLCO1B1SLC22A8SLCO1B3 | |
| Pravastatin SCHEMBL2175991 | 0.99 | HMGCR (0.98) | HMGCRALOX15SLCO1B1SLC22A8SLCO1B3 | |
| Pravastatin SCHEMBL6943019 | 0.98 | HMGCR (0.97) | HMGCRALOX15SLCO1B1SLC22A8SLCO1B3 | |
| Pravastatin SCHEMBL6317379 | 0.98 | HMGCR (0.97) | HMGCRALOX15SLCO1B1SLC22A8SLCO1B3 | |
| Pravastatin SCHEMBL899410 | 0.98 | HMGCR (0.97) | HMGCRALOX15SLCO1B1SLC22A8SLCO1B3 | |
| Pravastatin SCHEMBL25969 | 0.98 | HMGCR (0.97) | HMGCRALOX15SLCO1B1SLC22A8SLCO1B3 | |
| Pravastatin SCHEMBL2817795 | 0.98 | HMGCR (0.97) | HMGCRALOX15SLCO1B1SLC22A8SLCO1B3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 57367 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4329920-B1 | SYSTEM FOR CAPTURE OF CARBON DIOXIDE FROM A GAS MIXTURE | DIRECT AIR CAPTURE LLC (US) | 2026-02-11 | — | — | EP | claimed |
| US-20250332254-A1 | METHODS FOR TREATING PATIENTS WITH FAMILIAL HYPERCHOLESTEROLEMIA | REGENERON PHARMA (US) | 2025-10-30 | — | — | US | claimed |
| US-20250303156-A1 | CONCOMITANT TREATMENT OF TTFIELDS AND HMG-CO A REDUCTASE INHIBITORS | NOVOCURE GMBH (CH) | 2025-10-02 | — | — | US | claimed |
| WO-2025202988-A1 | CONCOMITANT TREATMENT WITH TTFIELDS AND HGM-COA REDUCTASE INHIBITORS | NOVOCURE GMBH (CH) | 2025-10-02 | — | — | WO | claimed |
| US-20250264469-A1 | METHODS FOR IMPROVING OUTCOMES FOR HEMATOPOIETIC CELL TRANSPLANT RECIPIENTS AT RISK FOR BRONCHIOLITIS OBLITERANS SYNDROME | CHILDREN'S HOSPITAL MEDICAL CENTER | 2025-08-21 | — | — | US | claimed |
| US-20250179219-A1 | CYCLODEXTRIN DIMERS, COMPOSITIONS THEREOF, AND USES THEREOF | CYCLARITY THERAPEUTICS INC (US) | 2025-06-05 | — | — | US | claimed |
| US-20250144067-A1 | PERSONALIZED STARVATION THERAPY FOR CANCER | FAETH THERAPEUTICS, INC. | 2025-05-08 | — | — | US | claimed |
| CN-119632944-A | Pravastatin sodium capsule and preparation method thereof | 南京百泽医药科技有限公司 | 2025-03-18 | — | — | CN | claimed |
| CN-119552080-A | Preparation method of high-purity pravastatin sodium D-type crystal | 广东蓝宝制药有限公司 | 2025-03-04 | — | — | CN | claimed |
| US-20240390364-A1 | Novel Pyridine Compositions and their use in methods for preventing or treating diseases, disorders and conditions | REID CHRISTOPHER BRIAN (US) | 2024-11-28 | — | — | US | claimed |
| WO-1991009955-A1 | ENDOGENOUS GENE EXPRESSION MODIFICATION WITH REGULATORY ELEMENT | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 1991-07-11 | — | — | WO | claimed |
| EP-0192719-B1 | METHOD AND APPARATUS FOR DETERMINING AT LEAST ONE CHARACTERISTIC VALUE OF MOVEMENT OF A BODY | Pötsch, Edmund R. (DE) | 1991-01-16 | — | — | EP | claimed |
| US-4947444-A | Image processing method and apparatus | FUJI XEROX CO., LTD. (JP) | 1990-08-07 | — | — | US | claimed |
| EP-0311185-A1 | Colour display tube including a colour selection electrode with edge | Koninklijke Philips Electronics N.V. (NL) | 1989-04-12 | — | — | EP | claimed |
| WO-1989000311-A1 | AUTOMATIC CLOCK DE-SKEWING ON A CIRCUIT BOARD | UNISYS CORPORATION (US) | 1989-01-12 | — | — | WO | claimed |
| EP-0192719-A1 | METHOD AND APPARATUS FOR DETERMINING AT LEAST ONE CHARACTERISTIC VALUE OF MOVEMENT OF A BODY. | POTSCH EDMUND R | 1986-09-03 | — | — | EP | claimed |
| WO-1986001607-A1 | METHOD AND APPARATUS FOR DETERMINING AT LEAST ONE CHARACTERISTIC VALUE OF MOVEMENT OF A BODY | POETSCH EDMUND R (DE) | 1986-03-13 | — | — | WO | claimed |
| US-4547860-A | Computer keyboards with few keys designating hundreds of functions | THE LAITRAM CORPORATION (US) | 1985-10-15 | — | — | US | claimed |
| EP-0129973-A1 | Magnetic disc memory apparatus incorporating temperature compensation | SEAGATE TECHNOLOGY (US) | 1985-01-02 | — | — | EP | claimed |
| US-4220275-A | Fastener selection system | THE BOEING COMPANY (US) | 1980-09-02 | — | — | US | claimed |