Pravastatin

Pravastatin

SCHEMBL25969

CC[C@H](C)C(=O)O[C@H]1C[C@H](O)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)[O-])[C@H]21.CC[C@H](C)C(=O)O[C@H]1C[C@H](O)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)[O-])[C@H]21.[Ca+2]

nearest known ligand 0.97

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

HMGCR

The experimentally established mechanism targets of Pravastatin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HMGCR known ✓ P04035 10/20 0.97
ALOX15 P16050 1/20 0.97
SLCO1B1 Q9Y6L6 3/20 0.84
SLC22A8 Q8TCC7 1/20 0.84
SLCO1B3 Q9NPD5 1/20 0.84
HDAC1 Q13547 2/20 0.69
HDAC2 Q92769 2/20 0.69
HDAC6 Q9UBN7 2/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pravastatin SCHEMBL2817795 0.98 HMGCR (0.97) HMGCRALOX15SLCO1B1SLC22A8SLCO1B3
Pravastatin SCHEMBL899410 0.98 HMGCR (0.97) HMGCRALOX15SLCO1B1SLC22A8SLCO1B3
Pravastatin SCHEMBL14472019 0.98 HMGCR (1.00) HMGCRALOX15SLCO1B1SLC22A8SLCO1B3
Pravastatin SCHEMBL3013 0.98 HMGCR (1.00) HMGCRALOX15SLCO1B1SLC22A8SLCO1B3
Pravastatin SCHEMBL5598406 0.98 HMGCR (1.00) HMGCRALOX15SLCO1B1SLC22A8SLCO1B3
Pravastatin SCHEMBL3014 0.98 HMGCR (1.00) HMGCRALOX15SLCO1B1SLC22A8SLCO1B3
Pravastatin SCHEMBL27522597 0.98 HMGCR (1.00) HMGCRALOX15SLCO1B1SLC22A8SLCO1B3
Pravastatin SCHEMBL6317379 0.98 HMGCR (0.97) HMGCRALOX15SLCO1B1SLC22A8SLCO1B3
Pravastatin SCHEMBL2225672 0.98 HMGCR (0.97) HMGCRALOX15SLCO1B1SLC22A8SLCO1B3
Pravastatin SCHEMBL2175991 0.97 HMGCR (0.98) HMGCRALOX15SLCO1B1SLC22A8SLCO1B3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 84 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108675931-A A kind of low barium statin calcium and preparation method thereof 合肥合源药业有限公司 2018-10-19 CN claimed
EP-3035933-A2 COMPOSITIONS AND THERAPEUTIC METHODS FOR ACCELERATED PLAQUE REGRESSION Resverlogix Corporation (CA) 2016-06-29 EP claimed
CN-104739855-A Statin-related drug composition as well as capsule preparation and preparation method thereof Zhaoke pharmaceutical guangzhou co ltd 2015-07-01 CN claimed
WO-2015025228-A2 COMPOSITIONS AND THERAPEUTIC METHODS FOR ACCELERATED PLAQUE REGRESSION RESVERLOGIX CORP. (CA) 2015-02-26 WO claimed
US-20140142127-A1 Stable Compositions of HMG-COA Reductase Inhibitors and Omega-3 Oils ALMBURG, LLC (US) 2014-05-22 US claimed
WO-2012140490-A2 PROCESS FOR PREPARING QUINOLINE DERIVATIVE AUROBINDO PHARMA LIMITED (IN) 2012-10-18 WO claimed
WO-2012025939-A1 PITAVASTATIN CALCIUM AND PROCESS FOR ITS PREPARATION CADILA HEALTHCARE LIMITED (IN) 2012-03-01 WO claimed
US-20110294841-A1 NOVEL STATIN PHARMACEUTICAL COMPOSITIONS AND RELATED METHODS OF TREATMENT GUZMAN HECTOR (US) 2011-12-01 US claimed
EP-2387561-A2 IMPROVED PROCESS FOR THE PREPARATION OF HIGHLY PURE (3R,5S)-7-Ý2-CYCLOPROPYL-4-(4-FLUOROPHENYL) QUINOLIN-3-YL¨-3,5-DIHYDROXY-6(E)-HEPTENOIC ACID AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF MSN Laboratories Limited (IN) 2011-11-23 EP claimed
WO-2010089770-A2 IMPROVED PROCESS FOR THE PREPARATION OF HIGHLY PURE (3R,5S)-7-[2-CYCLOPROPYL-4-(4-FLUOROPHENYL) QUINOLIN-3-YL]-3,5-DIHYDROXY-6(E)-HEPTENOIC ACID AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF MSN LABORATORIES LIMITED (IN) 2010-08-12 WO claimed
US-7772277-B2 Formulations comprising fenofibrate and a statin, and related methods of treatment TRANSFORM PHARMACEUTICALS, INC. (US) 2010-08-10 US claimed
US-7642287-B2 storage stable drug contains pravastatin calcium and an omega-3 oil, wherein the omega-3 oil comprises 46% ethyl ester of eicosapentaenoic acid, 38% ethyl ester of docosahexaenoic acid; anticholesterol agent, antilipemic agent; treating atherosclerosis, hyperlipidemia, cardiovascular disease TRANSFORM PHARMACEUTICALS, INC. (US) 2010-01-05 US claimed
EP-2086945-A2 NOVEL PROCESS FOR THE PREPARATION OF STATINS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF Satyanarayana Reddy, Manne (IN) 2009-08-12 EP claimed
CN-101500555-A Novel formulations comprising fenofibrate and a statin and related methods of treatment TRANSFORM PHARMACEUTICALS INC (US) 2009-08-05 CN claimed
WO-2008044243-A9 NOVEL PROCESS FOR THE PREPARATION OF STATINS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF SATYANARAYANA REDDY MANNE (IN) 2008-11-13 WO claimed
EP-1922065-A2 NOVEL FORMULATIONS COMPRISING FENOFIBRATE AND A STATIN, AND RELATED METHODS OF TREATMENT Transform Pharmaceuticals, Inc. (US) 2008-05-21 EP claimed
WO-2008044243-A2 NOVEL PROCESS FOR THE PREPARATION OF STATINS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF SATYANARAYANA REDDY MANNE (IN) 2008-04-17 WO claimed
WO-2007019373-A2 NOVEL FORMULATIONS COMPRISING FENOFIBRATE AND A STATIN, AND RELATED METHODS OF TREATMENT TRANSFORM PHARMACEUTICALS, INC. (US) 2007-02-15 WO claimed
US-20070032546-A1 NOVEL FORMULATIONS COMPRISING FENOFIBRATE AND A STATIN, AND RELATED METHODS OF TREATMENT ALMBURG, LLC 2007-02-08 US claimed
US-20240189221-A1 METHODS AND FORMULATIONS FOR TREATING VASCULAR DISEASE ENDOPERFUSION SOLUTIONS, LLC 2024-06-13 US disclosed
CN-116942850-B Nanometer drug delivery system for vulnerable plaque 北京茵诺医药科技有限公司 2023-12-05 CN disclosed
CN-116942850-A Nanometer drug delivery system for vulnerable plaque 北京茵诺医药科技有限公司 2023-10-27 CN disclosed
EP-3386503-B1 KITS FOR TREATING VASCULAR DISEASE ENDOPERFUSION SOLUTIONS LLC (US) 2022-06-22 EP disclosed
CN-111249248-B Blood lipid reducing medicine and preparation method thereof 北京阳光诺和药物研究股份有限公司 2021-03-05 CN disclosed
EP-3630125-A2 SENOLYTIC COMPOUNDS United Kingdom Research and Innovation (GB) 2020-04-08 EP disclosed
US-20180360742-A1 METHODS AND FORMULATIONS FOR TREATING VASCULAR DISEASE ENDOPERFUSION SOLUTIONS, LLC 2018-12-20 US disclosed
WO-2018215795-A2 SENOLYTIC COMPOUNDS UNITED KINGDOM RESEARCH AND INNOVATION (GB) 2018-11-29 WO disclosed
CN-108675931-A A kind of low barium statin calcium and preparation method thereof 合肥合源药业有限公司 2018-10-19 CN disclosed
EP-3386503-A1 METHODS AND FORMULATIONS FOR TREATING VASCULAR DISEASE Endoperfusion Solutions, LLC (US) 2018-10-17 EP disclosed
WO-2017100767-A1 METHODS AND FORMULATIONS FOR TREATING VASCULAR DISEASE ENDOPERFUSION SOLUTIONS, LLC (US) 2017-06-15 WO disclosed
EP-3131578-A1 COMPOSITIONS AND METHODS TO INCREASE PRODUCTION Novartis AG (CH) 2017-02-22 EP disclosed
EP-3054940-A1 COMPOSITIONS AND METHODS FOR TREATING NON-ALCOHOLIC STEATOHEPATITIS Mochida Pharmaceutical Co., Ltd. (JP) 2016-08-17 EP disclosed
EP-3035933-A2 COMPOSITIONS AND THERAPEUTIC METHODS FOR ACCELERATED PLAQUE REGRESSION Resverlogix Corporation (CA) 2016-06-29 EP disclosed
WO-2015158927-A1 COMPOSITIONS AND METHODS TO INCREASE PRODUCTION NOVARTIS AG (CH) 2015-10-22 WO disclosed
CN-104739855-A Statin-related drug composition as well as capsule preparation and preparation method thereof Zhaoke pharmaceutical guangzhou co ltd 2015-07-01 CN disclosed
WO-2015053379-A1 COMPOSITIONS AND METHODS FOR TREATING NON-ALCOHOLIC STEATOHEPATITIS MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2015-04-16 WO disclosed
WO-2015025228-A2 COMPOSITIONS AND THERAPEUTIC METHODS FOR ACCELERATED PLAQUE REGRESSION RESVERLOGIX CORP. (CA) 2015-02-26 WO disclosed
WO-2014195965-A2 AN IMPROVED PROCESS FOR THE PREPARATION OF HMG-COA REDUCTASE INHIBITOR INTERMEDIATES MYLAN LABORATORIES LTD (IN) 2014-12-11 WO disclosed
WO-2014108795-A2 AN IMPROVED PROCESS FOR THE PREPARATION OF CHIRAL DIOL SULFONES AND STATINS AUROBINDO PHARMA LIMITED (IN) 2014-07-17 WO disclosed
US-20140142127-A1 Stable Compositions of HMG-COA Reductase Inhibitors and Omega-3 Oils ALMBURG, LLC (US) 2014-05-22 US disclosed
CN-103784417-A Pravastatin calcium tablet containing magnesium silicate and preparation method thereof CHONGQING RUEPEAK PHARMACEUTICAL CO LTD 2014-05-14 CN disclosed
CN-103784417-A Pravastatin calcium tablet containing magnesium silicate and preparation method thereof CHONGQING RUEPEAK PHARMACEUTICAL CO LTD 2014-05-14 CN disclosed
CN-103690955-A Ticagrelor-containing drug composition as well as preparation method and application thereof FUZHOU QIANZHENG PHARMACEUTICAL CO LTD 2014-04-02 CN disclosed
WO-2013098773-A1 CRYSTALLINE FORMS OF PITAVASTATIN CALCIUM DR. REDDY'S LABORATORIES LIMITED (IN) 2013-07-04 WO disclosed
CN-102885797-A Composition containing pravastatin calcium as well as preparation method and application thereof FUZHOU NEPTUNUS FUYAO PHARMACEUTICAL CO LTD 2013-01-23 CN disclosed
CN-102885797-A Composition containing pravastatin calcium as well as preparation method and application thereof FUZHOU NEPTUNUS FUYAO PHARMACEUTICAL CO LTD 2013-01-23 CN disclosed
WO-2012106584-A2 PITAVASTATIN SALTS DR. REDDY'S LABORATORIES LTD. (IN) 2012-08-09 WO disclosed
US-8232295-B2 Treating vascular events with statins by inhibiting PAR-1 and PAR-4 HEARTDRUG RESEARCH, L.L.C. (US) 2012-07-31 US disclosed
WO-2010146348-A9 CRYSTALLINE FORM OF PEMIROLAST CARDOZ AB (SE) 2012-05-03 WO disclosed
EP-2443120-A2 NEW CRYSTALLINE FORM OF PEMIROLAST Cardoz AB (SE) 2012-04-25 EP disclosed
WO-2012025939-A1 PITAVASTATIN CALCIUM AND PROCESS FOR ITS PREPARATION CADILA HEALTHCARE LIMITED (IN) 2012-03-01 WO disclosed
US-20110294841-A1 NOVEL STATIN PHARMACEUTICAL COMPOSITIONS AND RELATED METHODS OF TREATMENT GUZMAN HECTOR (US) 2011-12-01 US disclosed
EP-2387561-A2 IMPROVED PROCESS FOR THE PREPARATION OF HIGHLY PURE (3R,5S)-7-Ý2-CYCLOPROPYL-4-(4-FLUOROPHENYL) QUINOLIN-3-YL¨-3,5-DIHYDROXY-6(E)-HEPTENOIC ACID AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF MSN Laboratories Limited (IN) 2011-11-23 EP disclosed
US-20110160236-A1 Treating Vascular Events with Statins by Inhibiting PAR-1 and PAR-4 HEARTDRUG RESEARCH, L.L.C. 2011-06-30 US disclosed
WO-2010146348-A2 NEW CRYSTALLINE FORM OF PEMIROLAST CARDOZ AB (SE) 2010-12-23 WO disclosed
US-7842716-B2 Treating vascular events with statins by inhibiting PAR-1 and PAR-4 HeartDrug Research, LLC (US) 2010-11-30 US disclosed
WO-2010089770-A2 IMPROVED PROCESS FOR THE PREPARATION OF HIGHLY PURE (3R,5S)-7-[2-CYCLOPROPYL-4-(4-FLUOROPHENYL) QUINOLIN-3-YL]-3,5-DIHYDROXY-6(E)-HEPTENOIC ACID AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF MSN LABORATORIES LIMITED (IN) 2010-08-12 WO disclosed
US-7772277-B2 Formulations comprising fenofibrate and a statin, and related methods of treatment TRANSFORM PHARMACEUTICALS, INC. (US) 2010-08-10 US disclosed
WO-2010077062-A2 PREPARATION METHOD OF STATIN COMPOUND AND BENZOTHIAZOLYL SULFONE COMPOUND USED THEREIN HANMI PHARM. CO., LTD. (KR) 2010-07-08 WO disclosed
US-7642287-B2 storage stable drug contains pravastatin calcium and an omega-3 oil, wherein the omega-3 oil comprises 46% ethyl ester of eicosapentaenoic acid, 38% ethyl ester of docosahexaenoic acid; anticholesterol agent, antilipemic agent; treating atherosclerosis, hyperlipidemia, cardiovascular disease TRANSFORM PHARMACEUTICALS, INC. (US) 2010-01-05 US disclosed
EP-2120919-A1 NEW COMBINATION FOR USE IN THE TREATMENT OF INFLAMMATORY DISORDERS Cardoz AB (SE) 2009-11-25 EP disclosed
EP-2104534-A1 NEW COMBINATION FOR USE IN THE TREATMENT OF INFLAMMATORY DISORDERS Cardoz AB (SE) 2009-09-30 EP disclosed
EP-2086945-A2 NOVEL PROCESS FOR THE PREPARATION OF STATINS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF Satyanarayana Reddy, Manne (IN) 2009-08-12 EP disclosed
US-20090182008-A1 CRYSTALLINE FORMS OF PITAVASTATIN CALCIUM NISSAN CHEMICAL INDUSTRIES LTD. (JP) 2009-07-16 US disclosed
CN-100506796-C Method for preparing high optical purity pitavastatin calcium raw material drug SHANGHAI YAOMING KANGDE NEW ME (CN) 2009-07-01 CN disclosed
EP-2024341-A2 NOVEL PROCESS FOR STATINS AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF Satynarayana Reddy, Manne (IN) 2009-02-18 EP disclosed
US-20090042979-A1 Novel Statin Pharmaceutical Compositions and Related Methods of Treatment TRANSFORM PHARMACEUTICALS INC. (US) 2009-02-12 US disclosed
WO-2008044243-A9 NOVEL PROCESS FOR THE PREPARATION OF STATINS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF SATYANARAYANA REDDY MANNE (IN) 2008-11-13 WO disclosed
WO-2008087371-A1 NEW COMBINATION FOR USE IN THE TREATMENT OF INFLAMMATORY DISORDERS CARDOZ AB (SE) 2008-07-24 WO disclosed
WO-2008074975-A1 NEW COMBINATION FOR USE IN THE TREATMENT OF INFLAMMATORY DISORDERS CARDOZ AB (SE) 2008-06-26 WO disclosed
WO-2008044243-A2 NOVEL PROCESS FOR THE PREPARATION OF STATINS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF SATYANARAYANA REDDY MANNE (IN) 2008-04-17 WO disclosed
EP-1786414-A4 NOVEL STATIN PHARMACEUTICAL COMPOSITIONS AND RELATED METHODS OF TREATMENT TRANSFORM PHARMACEUTICALS INC (US) 2008-04-09 EP disclosed
WO-2007132482-A2 NOVEL PROCESS FOR THE PREPARATION OF PITAVASTATIN AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS SATYANARAYANA REDDY MANNE (IN) 2007-11-22 WO disclosed
WO-2007130714-A1 NOVEL STATIN PHARMACEUTICAL COMPOSITIONS AND RELATED METHODS OF TREATMENT TRANSFORM PHARMACEUTICALS, INC. (US) 2007-11-15 WO disclosed
WO-2007125547-A2 NOVEL PROCESS FOR STATINS AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF SATYANARAYANA REDDY MANNE (IN) 2007-11-08 WO disclosed
CN-1993121-A Novel statin pharmaceutical compositions and related methods of treatment TRANSFORM PHARMACEUTICALS INC (US) 2007-07-04 CN disclosed
EP-1786414-A2 NOVEL STATIN PHARMACEUTICAL COMPOSITIONS AND RELATED METHODS OF TREATMENT Transform Pharmaceuticals, Inc. (US) 2007-05-23 EP disclosed
EP-1755607-A2 COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE Pharmix Corporation (US) 2007-02-28 EP disclosed
CN-1876633-A Method for preparing high optical purity pitavastatin calcium raw material drug SHANGHAI YAOMING KANGDE NEW ME (CN) 2006-12-13 CN disclosed
WO-2006058943-A1 METHOD OF OBTAINING PURIFIED PRAVASTATIN SODIUM ERCROS INDUSTRIAL, S.A. (ES) 2006-06-08 WO disclosed
WO-2006028524-A2 COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE PHARMIX CORPORATION (US) 2006-03-16 WO disclosed
US-20060034815-A1 Novel statin pharmaceutical compositions and related methods of treatment ALMBURG, LLC 2006-02-16 US disclosed
WO-2006017698-A2 NOVEL STATIN PHARMACEUTICAL COMPOSITIONS AND RELATED METHODS OF TREATMENT TRANSFORM PHARMACEUTICALS, INC. (US) 2006-02-16 WO disclosed
US-20050215618-A1 Treating vascular events with statins by inhibiting PAR-1 and PAR-4 HEARTDRUG RESEARCH, L.L.C. 2005-09-29 US disclosed
US-20050215618-A1 Treating vascular events with statins by inhibiting PAR-1 and PAR-4 HEARTDRUG RESEARCH, L.L.C. 2005-09-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240189221-A1 METHODS AND FORMULATIONS FOR TREATING VASCULAR DISEASE LIPG, APOB, LIPA HMGCR 5/4885ALOX15 255/4885SLCO1B1 1066/4885
US-20090182008-A1 CRYSTALLINE FORMS OF PITAVASTATIN CALCIUM CTSC, CACYBP, CA4 HMGCR 345/4885ALOX15 4690/4885SLCO1B1 239/4885
US-20180360742-A1 METHODS AND FORMULATIONS FOR TREATING VASCULAR DISEASE LIPG, APOB, LIPA HMGCR 5/4885ALOX15 255/4885SLCO1B1 1066/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.