Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.34 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 3/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23723650 | 1.00 | PDE9A (0.38) | PDE9AALDH1A1POLBUSP2GLA | |
| SCHEMBL23723619 | 0.89 | GRM5 (0.41) | PDE9AALDH1A1POLBTSHRSMN1; SMN2 | |
| SCHEMBL30132061 | 0.89 | GRM5 (0.41) | PDE9AALDH1A1POLBTSHRSMN1; SMN2 | |
| SCHEMBL30132094 | 0.87 | TSHR (0.42) | PDE9AALDH1A1POLBRAB9ATSHR | |
| SCHEMBL23723520 | 0.87 | TSHR (0.42) | PDE9AALDH1A1POLBRAB9ATSHR | |
| SCHEMBL23723808 | 0.86 | GRM1 (0.38) | ALDH1A1RAB9ATSHRSMN1; SMN2NPC1 | |
| SCHEMBL30132062 | 0.86 | GRM1 (0.38) | ALDH1A1RAB9ATSHRSMN1; SMN2NPC1 | |
| SCHEMBL23723609 | 0.85 | SMN1; SMN2 (0.42) | PDE9AALDH1A1POLBTSHRSMN1; SMN2 | |
| SCHEMBL30132074 | 0.85 | SMN1; SMN2 (0.42) | PDE9AALDH1A1POLBTSHRSMN1; SMN2 | |
| SCHEMBL23723692 | 0.84 | MAPT (0.40) | ALDH1A1POLBRAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100015-A1 | COMBINATION THERAPY FOR TREATING MPS1 | Gain Therapeutics SA (CH) | 2022-12-14 | — | — | EP | disclosed |