Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GBA1 | P04062 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | ALPI | P09923 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26521632 | 1.00 | PARP1 (0.54) | PARP1MAPTLMNATSHRRAB9A | |
| SCHEMBL26521647 | 0.93 | PARP1 (0.54) | PARP1MAPTLMNATSHRRAB9A | |
| SCHEMBL23723559 | 0.90 | ALDH1A1 (0.52) | PARP1MAPTLMNATSHRRAB9A | |
| SCHEMBL26524354 | 0.85 | MAPT (0.51) | PARP1MAPTLMNATSHRALDH1A1 | |
| SCHEMBL23723748 | 0.85 | MAPT (0.51) | PARP1MAPTLMNATSHRRAB9A | |
| SCHEMBL23749976 | 0.84 | PARP1 (0.61) | PARP1MAPTLMNATSHRSMN1; SMN2 | |
| SCHEMBL26521585 | 0.83 | TSHR (0.48) | PARP1MAPTLMNATSHRRAB9A | |
| SCHEMBL30132126 | 0.83 | TSHR (0.48) | PARP1MAPTLMNATSHRRAB9A | |
| SCHEMBL26521975 | 0.80 | MAPT (0.46) | MAPTTSHRRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL23882083 | 0.78 | ALDH1A1 (0.51) | PARP1MAPTLMNARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100015-A1 | COMBINATION THERAPY FOR TREATING MPS1 | Gain Therapeutics SA (CH) | 2022-12-14 | — | — | EP | disclosed |