Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 12/20 | 0.57 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 13/20 | 0.38 |
| ▸ | HTR2C | P28335 | 9/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 6/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | CASP9 | P55211 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.34 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.34 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13244502 | 0.83 | HRH1 (0.52) | HRH1MAOAHTR2AHTR2CDRD2 | |
| SCHEMBL13004185 | 0.75 | MEN1 (0.44) | HRH1MAOAHTR2AHTR2CDRD2 | |
| SCHEMBL3001180 | 0.74 | MAOA (0.47) | HRH1MAOAHTR2AHTR2CDRD2 | |
| SCHEMBL3011977 | 0.72 | MAOA (0.42) | HRH1MAOAHTR2AHTR2CDRD2 | |
| SCHEMBL3766701 | 0.72 | HTR2A (0.54) | HRH1MAOAHTR2AHTR2CDRD2 | |
| SCHEMBL14707058 | 0.69 | HTR2A (0.49) | HTR2AHTR2CHTR2B | |
| SCHEMBL14707059 | 0.67 | HTR2A (0.44) | HTR2A | |
| SCHEMBL23645474 | 0.66 | MAPK1 (0.37) | MAOAHTR2AKCNH2 | |
| SCHEMBL3017859 | 0.66 | KDM1A (0.37) | HRH1HTR2AHTR2CDRD2SLC6A2 | |
| SCHEMBL11637284 | 0.65 | GSK3B (0.38) | HRH1TDP2CASP3CASP7CASP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100311734-A1 | Spiro Compounds Useful as Antagonists of the H1 Receptor | GLAXO GROUP LIMITED | 2010-12-09 | — | — | US | disclosed |
| US-20100311734-A1 | Spiro Compounds Useful as Antagonists of the H1 Receptor | GLAXO GROUP LIMITED | 2010-12-09 | — | — | US | disclosed |
| US-20100311734-A1 | Spiro Compounds Useful as Antagonists of the H1 Receptor | GLAXO GROUP LIMITED | 2010-12-09 | — | — | US | disclosed |
| US-20100190764-A1 | Novel compounds | GLAXO GROUP LIMITED | 2010-07-29 | — | — | US | disclosed |
| US-20100190764-A1 | Novel compounds | GLAXO GROUP LIMITED | 2010-07-29 | — | — | US | disclosed |
| US-20100190764-A1 | Novel compounds | GLAXO GROUP LIMITED | 2010-07-29 | — | — | US | disclosed |
| EP-2178823-A1 | SPIRO CYCLOPENTANE COMPOUNDS USEFUL AS ANTAGONISTS OF THE H1-RECEPTOR | Glaxo Group Limited (GB) | 2010-04-28 | — | — | EP | disclosed |
| EP-2170807-A1 | SPIRO COMPOUNDS USEFUL AS ANTAGONISTS OF THE H1 RECEPTOR | Glaxo Group Limited (GB) | 2010-04-07 | — | — | EP | disclosed |
| WO-2009016085-A1 | SPIRO COMPOUNDS USEFUL AS ANTAGONISTS OF THE H1 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2009-02-05 | — | — | WO | disclosed |
| WO-2009016085-A1 | SPIRO COMPOUNDS USEFUL AS ANTAGONISTS OF THE H1 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2009-02-05 | — | — | WO | disclosed |
| WO-2009016084-A1 | SPIRO CYCLOPENTANE COMPOUNDS USEFUL AS ANTAGONISTS OF THE H1-RECEPTOR | GLAXO GROUP LIMITED (GB) | 2009-02-05 | — | — | WO | disclosed |
| WO-2009016084-A1 | SPIRO CYCLOPENTANE COMPOUNDS USEFUL AS ANTAGONISTS OF THE H1-RECEPTOR | GLAXO GROUP LIMITED (GB) | 2009-02-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190764-A1 | Novel compounds | HCRTR1, HCRTR2, CNR1 | HRH1 382/4885MAOA 1499/4885HTR2A 596/4885 |
| US-20100311734-A1 | Spiro Compounds Useful as Antagonists of the H1 Receptor | HCRTR1, HCRTR2, HRH3 | HRH1 4/4885MAOA 888/4885HTR2A 137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.