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Dynorphin A (1-11)

Dynorphin A (1-11)

SCHEMBL30132402

CC[C@H](C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)O

nearest known ligand 0.86

Full drug profile on Sugi Atlas →

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ OPRD1 P41143 8/20 0.86
▸ NTSR1 P30989 7/20 0.77
▸ OPRM1 P35372 1/20 0.77
▸ OPRK1 P41145 1/20 0.77
▸ NTSR2 O95665 3/20 0.74
▸ SORT1 Q99523 2/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Analog Of Dynorphin A SCHEMBL29389694 1.00 OPRD1 (0.86) OPRD1NTSR1OPRM1OPRK1NTSR2
SCHEMBL29878209 0.99 OPRD1 (0.85) OPRD1NTSR1OPRM1OPRK1NTSR2
SCHEMBL29648931 0.97 OPRD1 (0.90) OPRD1NTSR1OPRM1OPRK1NTSR2
SCHEMBL31009049 0.97 OPRD1 (0.88) OPRD1NTSR1OPRM1OPRK1NTSR2
SCHEMBL29386868 0.94 OPRD1 (0.82) OPRD1NTSR1OPRM1OPRK1
SCHEMBL31197421 0.92 OPRD1 (0.77) OPRD1NTSR1OPRM1OPRK1NTSR2
SCHEMBL11191224 0.92 OPRD1 (0.75) OPRD1NTSR1OPRM1OPRK1NTSR2
Analog Of Dynorphin A SCHEMBL27861937 0.92 OPRD1 (0.75) OPRD1NTSR1OPRM1OPRK1NTSR2
Dynorphin A (1-17) SCHEMBL29599476 0.89 OPRD1 (0.70) OPRD1NTSR1OPRM1OPRK1NTSR2
Dynorphin A (1-17) SCHEMBL29358748 0.89 OPRD1 (0.70) OPRD1NTSR1OPRM1OPRK1NTSR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115697371-A Macrocyclic oligopeptides in combination with kappa opioid receptor ligands for MS therapy 维也纳医科大学 2023-02-03 — — CN claimed
EP-4121085-A1 CYCLOTIDES IN COMBINATION WITH KAPPA OPIOID RECEPTOR LIGANDS FOR MS THERAPY Medizinische Universität Wien (AT) 2023-01-25 — — EP claimed
CN-115697371-A Macrocyclic oligopeptides in combination with kappa opioid receptor ligands for MS therapy 维也纳医科大学 2023-02-03 — — CN disclosed
EP-4121085-A1 CYCLOTIDES IN COMBINATION WITH KAPPA OPIOID RECEPTOR LIGANDS FOR MS THERAPY Medizinische Universität Wien (AT) 2023-01-25 — — EP disclosed
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