Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27238440 | 0.84 | MAPT (0.39) | MAPTALDH1A1LMNANPC1HTT | |
| SCHEMBL30133168 | 0.82 | MAPT (0.38) | MAPTALDH1A1LMNANPC1HTT | |
| SCHEMBL30133164 | 0.82 | MAPT (0.38) | MAPTALDH1A1LMNANPC1HTT | |
| SCHEMBL29281266 | 0.79 | ALDH1A1 (0.41) | MAPTALDH1A1LMNANPC1HTT | |
| SCHEMBL138626 | 0.79 | ALDH1A1 (0.48) | MAPTALDH1A1LMNANPC1HTT | |
| SCHEMBL30133094 | 0.79 | PDE4B (0.43) | MAPTALDH1A1LMNANPC1HTT | |
| SCHEMBL30133157 | 0.75 | MAPT (0.53) | MAPTALDH1A1LMNANPC1HTT | |
| SCHEMBL30133117 | 0.73 | ALDH1A1 (0.63) | MAPTALDH1A1LMNAHPGDKDM4E | |
| SCHEMBL29207627 | 0.72 | MAPT (0.66) | MAPTALDH1A1LMNANPC1RAB9A | |
| SCHEMBL29207717 | 0.70 | ALDH1A1 (0.49) | MAPTALDH1A1LMNANPC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4380940-A1 | NEW CYCLOPENTA-THIENO-DIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | F. Hoffmann-La Roche AG (CH) | 2024-06-12 | — | — | EP | disclosed |
| WO-2023012130-A1 | NEW CYCLOPENTA-THIENO-DIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | F. HOFFMANN-LA ROCHE AG (CH) | 2023-02-09 | — | — | WO | disclosed |