⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4618635 | 0.91 | — | — | |
| SCHEMBL4563380 | 0.65 | CRBN (0.35) | — | |
| Cyclopentanone SCHEMBL28195072 | 0.65 | TRIM24 (0.59) | — | |
| SCHEMBL6653643 | 0.61 | TRIM24 (0.45) | — | |
| SCHEMBL1902980 | 0.59 | — | — | |
| Cyclohexanone SCHEMBL435383 | 0.56 | — | — | |
| Cyclohexanone SCHEMBL28194025 | 0.56 | — | — | |
| Cycloheptanone SCHEMBL28193490 | 0.56 | — | — | |
| SCHEMBL33935 | 0.54 | — | — | |
| SCHEMBL17971494 | 0.54 | TRIM24 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7344656-B2 | Storing a composition in an alcoholic gel | TRUOX, INC. (US) | 2008-03-18 | — | — | US | claimed |
| EP-1565442-B1 | PYRIDINE DERIVATIVES AS CB2 RECEPTOR MODULATORS | GLAXO GROUP LTD (GB) | 2007-11-14 | — | — | EP | claimed |
| EP-2178870-B1 | INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG CHEMICAL LTD (KR) | 2018-09-19 | — | — | EP | disclosed |
| US-9000028-B2 | Indole and indazole compounds as an inhibitor of cellular necrosis | LG LIFE SCIENCES LTD. (KR) | 2015-04-07 | — | — | US | disclosed |
| US-20130237532-A1 | INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG LIFE SCIENCES LTD. (KR) | 2013-09-12 | — | — | US | disclosed |
| US-8436038-B2 | Indole and indazole compounds as an inhibitor of cellular necrosis | LG LIFE SCIENCES LTD. (KR) | 2013-05-07 | — | — | US | disclosed |
| US-20100197673-A1 | INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG LIFE SCIENCES LTD (KR) | 2010-08-05 | — | — | US | disclosed |
| EP-2178870-A1 | INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG Life Sciences Ltd. (KR) | 2010-04-28 | — | — | EP | disclosed |
| WO-2009025478-A1 | INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG LIFE SCIENCES LTD. (KR) | 2009-02-26 | — | — | WO | disclosed |
| US-5352802-A | Derivatives of 4H-thiopyran-1,1-dioxide | EASTMAN KODAK COMPANY (US) | 1994-10-04 | — | — | US | disclosed |
| US-5300385-A | Low voltage, high speed | EASTMAN KODAK COMPANY (US) | 1994-04-05 | — | — | US | disclosed |