Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.33 |
| ▸ | TRIM33 | Q9UPN9 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4618635 | 0.67 | — | — | |
| SCHEMBL3013362 | 0.65 | — | — | |
| SCHEMBL9323692 | 0.62 | — | — | |
| SCHEMBL276387 | 0.62 | — | — | |
| SCHEMBL8467316 | 0.59 | — | — | |
| SCHEMBL289021 | 0.59 | — | — | |
| SCHEMBL3107242 | 0.59 | — | — | |
| SCHEMBL1566729 | 0.59 | TRIM24 (0.82) | CRBNTRIM24TRIM33ALDH1A1 | |
| SCHEMBL3111600 | 0.59 | — | — | |
| SCHEMBL3002760 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1380573-B1 | Isoquinolines and preparation thereof | AVERA PHARMACEUTICALS INC (US) | 2009-05-06 | — | — | EP | disclosed |
| EP-0971898-B1 | SUBSTITUTED ISOQUINOLINES AS ULTRA SHORT ACTING NEUROMUSCULAR BLOCKERS | AVERA PHARMACEUTICALS INC (US) | 2005-05-11 | — | — | EP | disclosed |
| EP-1526130-A1 | Substituted isoquinolines as ultra short acting neuromuscular blockers | Avera Pharmaceuticals, Inc. (US) | 2005-04-27 | — | — | EP | disclosed |
| EP-1380573-A2 | Isoquinolines and preparation thereof | Avera Pharmaceuticals, Inc. (US) | 2004-01-14 | — | — | EP | disclosed |
| EP-0975599-B1 | SUBTITUTED ISOQUINOLINES AS ULTRA SHORT ACTING NEUROMUSCULAR BLOCKERS | AVERA PHARMACEUTICALS INC (US) | 2003-11-12 | — | — | EP | disclosed |
| US-6187789-B1 | MUSCLE RELAXANTS FOR EMERGENCY INTUBATION AND SURGERY | GLAXO WELLCOME INC. | 2001-02-13 | — | — | US | disclosed |
| US-6177445-B1 | MUSCLE RELAXANTS | GLAXO WELLCOME INC. | 2001-01-23 | — | — | US | disclosed |
| EP-0975599-A1 | SUBTITUTED ISOQUINOLINES AS ULTRA SHORT ACTING NEUROMUSCULAR BLOCKERS | GLAXO GROUP LIMITED (GB) | 2000-02-02 | — | — | EP | disclosed |
| EP-0971898-A1 | SUBSTITUTED ISOQUINOLINES AS ULTRA SHORT ACTING NEUROMUSCULAR BLOCKERS | GLAXO GROUP LIMITED (GB) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998042674-A1 | SUBSTITUTED ISOQUINOLINES AS ULTRA SHORT ACTING NEUROMUSCULAR BLOCKERS | GLAXO GROUP LIMITED (GB) | 1998-10-01 | — | — | WO | disclosed |
| WO-1998042675-A1 | SUBSTITUTED ISOQUINOLINES AS ULTRA SHORT ACTING NEUROMUSCULAR BLOCKERS | GLAXO GROUP LIMITED (GB) | 1998-10-01 | — | — | WO | disclosed |