SCHEMBL30134665

SCHEMBL30134665

COc1cccc(OC)c1-n1c(NS(=O)(=O)C(C)C(OC(C)C)c2ncc(C)cn2)nnc1-c1cncc(C)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
APLNR P35414 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29219024 1.00 APLNR (1.00) APLNR
SCHEMBL21097408 1.00 APLNR (1.00) APLNR
SCHEMBL30134660 1.00 APLNR (1.00) APLNR
SCHEMBL18245634 1.00 APLNR (1.00) APLNR
SCHEMBL18246012 1.00 APLNR (1.00) APLNR
SCHEMBL18531483 1.00 APLNR (1.00) APLNR
SCHEMBL18247139 1.00 APLNR (1.00) APLNR
SCHEMBL18247127 1.00 APLNR (1.00) APLNR
SCHEMBL18531539 0.95 APLNR (1.00) APLNR
SCHEMBL18531538 0.95 APLNR (1.00) APLNR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4646220-A1 COMBINATION THERAPY OF APELIN RECEPTOR AGONIST AND GLP-1 RECEPTOR AGONIST FOR TREATING A DISEASE OR CONDITION ASSOCIATED WITH WEIGHT GAIN Bioage Labs, Inc. (US) 2025-11-12 EP disclosed
EP-4593815-A1 APELIN RECEPTOR AGONISTS FOR TREATING MUSCLE CONDITIONS Bioage Labs, Inc. (US) 2025-08-06 EP disclosed
EP-4532015-A1 APELIN RECEPTOR MODULATORS FOR TREATMENT OF A DISORDER OR DISEASE ASSOCIATED WITH BBB PERMEABILITY Bioage Labs, Inc. (US) 2025-04-09 EP disclosed
CN-119546323-A Apelin peptide receptor modulators for the treatment of disorders or diseases related to BBB permeability 百爱及生物医药公司 2025-02-28 CN disclosed
WO-2024148104-A1 COMBINATION THERAPY OF APELIN RECEPTOR AGONIST AND GLP-1 RECEPTOR AGONIST FOR TREATING A DISEASE OR CONDITION ASSOCIATED WITH WEIGHT GAIN BioAge Labs, Inc. (US) 2024-07-11 WO disclosed
CN-117897157-A Apelin receptor modulators for the treatment of age-related muscle disorders 百爱及生物医药公司 2024-04-16 CN disclosed
WO-2024072907-A1 APELIN RECEPTOR AGONISTS FOR TREATING MUSCLE CONDITIONS BioAge Labs, Inc. (US) 2024-04-04 WO disclosed
EP-4319873-A1 APELIN RECEPTOR MODULATORS FOR TREATING AGE-RELATED MUSCLE CONDITIONS Bioage Labs, Inc. (US) 2024-02-14 EP disclosed
WO-2023235360-A1 APELIN RECEPTOR MODULATORS FOR TREATMENT OF A DISORDER OR DISEASE ASSOCIATED WITH BBB PERMEABILITY BioAge Labs, Inc. (US) 2023-12-07 WO disclosed
WO-2022216871-A1 APELIN RECEPTOR MODULATORS FOR TREATING AGE-RELATED MUSCLE CONDITIONS BioAge Labs, Inc. (US) 2022-10-13 WO disclosed