Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 14/20 | 0.55 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.55 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.55 |
| ▸ | FAP | Q12884 | 2/20 | 0.55 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.55 |
| ▸ | PREP | P48147 | 5/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15129601 | 1.00 | DPP4 (0.55) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL15129602 | 1.00 | DPP4 (0.55) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL25386940 | 1.00 | DPP4 (0.55) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL15129726 | 0.83 | DPP4 (0.68) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL15129725 | 0.83 | DPP4 (0.68) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL15129935 | 0.82 | DPP4 (0.68) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL15129937 | 0.82 | DPP4 (0.68) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL354762 | 0.81 | PREP (0.69) | DPP4DPP8DPP9DPP7PREP | |
| SCHEMBL6256625 | 0.81 | PREP (0.69) | DPP4DPP8DPP9DPP7PREP | |
| SCHEMBL21056857 | 0.80 | PREP (0.53) | DPP4DPP8DPP9FAPDPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373529-A1 | FIBROBLAST ACTIVATION PROTEIN INHIBITORS AND USE THEREOF | 3B Pharmaceuticals GmbH (DE) | 2024-05-29 | — | — | EP | disclosed |
| WO-2023002045-A1 | FIBROBLAST ACTIVATION PROTEIN INHIBITORS AND USE THEREOF | 3B PHARMACEUTICALS GMBH (DE) | 2023-01-26 | — | — | WO | disclosed |