Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 16/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21384398 | 0.86 | SMN1; SMN2 (0.52) | LMNAPOLBSMN1; SMN2OPRD1OPRK1 | |
| SCHEMBL29502235 | 0.85 | LMNA (0.49) | LMNAPOLBSMN1; SMN2OPRD1OPRK1 | |
| SCHEMBL30225407 | 0.85 | SMN1; SMN2 (0.54) | LMNAPOLBSMN1; SMN2OPRD1OPRK1 | |
| SCHEMBL30177238 | 0.83 | SMN1; SMN2 (0.52) | LMNAPOLBSMN1; SMN2OPRD1OPRK1 | |
| SCHEMBL726694 | 0.81 | SMN1; SMN2 (0.56) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL30002152 | 0.81 | SMN1; SMN2 (0.50) | LMNAPOLBSMN1; SMN2OPRD1OPRK1 | |
| SCHEMBL27832780 | 0.81 | SMN1; SMN2 (0.50) | LMNAPOLBSMN1; SMN2OPRD1OPRK1 | |
| SCHEMBL30136018 | 0.80 | LMNA (0.55) | LMNAPOLBSMN1; SMN2OPRD1OPRK1 | |
| SCHEMBL30177282 | 0.78 | LMNA (0.50) | LMNAPOLBSMN1; SMN2OPRD1OPRK1 | |
| SCHEMBL31693845 | 0.78 | SMN1; SMN2 (0.44) | LMNAPOLBSMN1; SMN2OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4384521-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | Uppthera, Inc. (KR) | 2024-06-19 | — | — | EP | disclosed |
| WO-2023017446-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |
| WO-2023018237-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |