Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 17/20 | 0.55 |
| ▸ | DDB1 | Q16531 | 15/20 | 0.55 |
| ▸ | IKZF3 | Q9UKT9 | 3/20 | 0.50 |
| ▸ | TNF | P01375 | 1/20 | 0.50 |
| ▸ | IL1B | P01584 | 1/20 | 0.50 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.50 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.50 |
| ▸ | HPGDS | O60760 | 2/20 | 0.49 |
| ▸ | GRAMD1A | Q96CP6 | 2/20 | 0.47 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29259959 | 1.00 | CRBN (0.55) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL20294709 | 0.93 | CRBN (0.59) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL31277299 | 0.90 | CRBN (0.55) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL30906277 | 0.90 | CRBN (0.49) | CRBNDDB1HPGDSGRAMD1A | |
| SCHEMBL24819464 | 0.90 | CRBN (0.54) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL30738833 | 0.90 | CRBN (0.54) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL30732167 | 0.90 | CRBN (0.54) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL26925221 | 0.90 | CRBN (0.54) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL26656828 | 0.90 | CRBN (0.54) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL25575583 | 0.89 | CRBN (0.59) | CRBNDDB1IKZF3MAP1LC3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4384520-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | Uppthera, Inc. (KR) | 2024-06-19 | — | — | EP | disclosed |
| WO-2023017446-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |
| WO-2023017442-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |