Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 4/20 | 0.39 |
| ▸ | HRH1 | P35367 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 2/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29923989 | 0.91 | SMN1; SMN2 (0.49) | POLBSMN1; SMN2LMNAOPRD1OPRK1 | |
| SCHEMBL1269471 | 0.85 | TSHR (0.49) | POLBSMN1; SMN2LMNAATMALDH1A1 | |
| SCHEMBL15569374 | 0.83 | POLB (0.50) | POLBSMN1; SMN2LMNAOPRD1OPRK1 | |
| SCHEMBL15569373 | 0.83 | POLB (0.50) | POLBSMN1; SMN2LMNAOPRD1OPRK1 | |
| SCHEMBL31386109 | 0.82 | POLB (0.52) | POLBSMN1; SMN2LMNAOPRD1OPRK1 | |
| SCHEMBL27842859 | 0.81 | POLB (0.58) | POLBSMN1; SMN2LMNAOPRD1OPRK1 | |
| SCHEMBL12328494 | 0.81 | POLB (0.51) | POLBSMN1; SMN2LMNAOPRD1OPRK1 | |
| SCHEMBL346648 | 0.80 | SMN1; SMN2 (0.56) | POLBSMN1; SMN2LMNAOPRD1OPRK1 | |
| SCHEMBL30136060 | 0.80 | POLB (0.56) | POLBSMN1; SMN2LMNAOPRD1OPRK1 | |
| SCHEMBL9405372 | 0.80 | POLB (0.73) | POLBSMN1; SMN2LMNAATMHRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4157849-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | Uppthera, Inc. (KR) | 2023-04-05 | — | — | EP | disclosed |
| WO-2023017446-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |
| WO-2023018238-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |