Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | HRH2 | P25021 | 5/20 | 0.51 |
| ▸ | HRH1 | P35367 | 5/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14590615 | 0.92 | POLB (0.65) | POLBSMN1; SMN2LMNAALDH1A1HRH2 | |
| SCHEMBL27826063 | 0.92 | SMN1; SMN2 (0.65) | POLBSMN1; SMN2LMNAALDH1A1HRH2 | |
| SCHEMBL5594524 | 0.92 | POLB (0.65) | POLBSMN1; SMN2LMNAALDH1A1HRH2 | |
| SCHEMBL5594520 | 0.92 | POLB (0.65) | POLBSMN1; SMN2LMNAALDH1A1HRH2 | |
| SCHEMBL1859157 | 0.92 | SMN1; SMN2 (0.69) | POLBSMN1; SMN2LMNAALDH1A1HRH2 | |
| SCHEMBL3634052 | 0.92 | SMN1; SMN2 (0.69) | POLBSMN1; SMN2LMNAALDH1A1HRH2 | |
| SCHEMBL6129170 | 0.92 | POLB (0.64) | POLBSMN1; SMN2LMNAALDH1A1HRH2 | |
| SCHEMBL29737753 | 0.91 | POLB (0.63) | POLBSMN1; SMN2LMNAALDH1A1HRH2 | |
| SCHEMBL1826048 | 0.90 | SMN1; SMN2 (0.67) | POLBSMN1; SMN2LMNAALDH1A1HRH2 | |
| SCHEMBL7838421 | 0.90 | SMN1; SMN2 (0.67) | POLBSMN1; SMN2LMNAALDH1A1HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170183365-A1 | MACROCYCLES | LUMIPHORE, INC. | 2017-06-29 | — | — | US | disclosed |
| EP-0595924-A4 | PLATELET ACTIVATING FACTOR ANTAGONISTS | ABBOTT LAB (US) | 1994-08-24 | — | — | EP | disclosed |
| EP-0595924-A1 | PLATELET ACTIVATING FACTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 1994-05-11 | — | — | EP | disclosed |
| WO-1993001813-A1 | PLATELET ACTIVATING FACTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 1993-02-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170183365-A1 | MACROCYCLES | HCCS, ABCB7, AURKAIP1 | POLB 1199/4885SMN1; SMN2 2561/4885LMNA 3079/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.