Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 11/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 6/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25937176 | 0.88 | DDB1 (0.43) | CRBNDDB1 | |
| SCHEMBL25031448 | 0.88 | DDB1 (0.43) | CRBNDDB1 | |
| SCHEMBL30135729 | 0.88 | CRBN (0.44) | CRBNDDB1NPC1FFAR4ESR1 | |
| SCHEMBL30135798 | 0.88 | ALDH1A1 (0.38) | CRBNDDB1ESR1GAA | |
| SCHEMBL30135834 | 0.85 | ALDH1A1 (0.38) | CRBNDDB1GAA | |
| SCHEMBL25301480 | 0.84 | CRBN (0.37) | CRBNDDB1ESR1GSPT1GAA | |
| SCHEMBL25262031 | 0.84 | CRBN (0.37) | CRBNDDB1ESR1GSPT1GAA | |
| SCHEMBL30981249 | 0.83 | CRBN (0.43) | CRBNDDB1ESR1GSPT1 | |
| SCHEMBL25941035 | 0.83 | CRBN (0.43) | CRBNDDB1ESR1GSPT1 | |
| SCHEMBL25336380 | 0.81 | CRBN (0.37) | CRBNDDB1ESR1POLBGSPT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4157850-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | Uppthera, Inc. (KR) | 2023-04-05 | — | — | EP | disclosed |
| EP-4157849-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | Uppthera, Inc. (KR) | 2023-04-05 | — | — | EP | disclosed |
| WO-2023018236-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |
| WO-2023017446-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |
| WO-2023018238-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |