Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 3/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | HRH2 | P25021 | 3/20 | 0.35 |
| ▸ | HRH1 | P35367 | 3/20 | 0.35 |
| ▸ | TNKS | O95271 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30135800 | 0.87 | CRBN (0.50) | DDB1CRBNPARP1TNKSDRD2 | |
| SCHEMBL25935497 | 0.87 | CRBN (0.50) | DDB1CRBNPARP1TNKSDRD2 | |
| SCHEMBL30135942 | 0.86 | SOS1 (0.42) | CRBNPOLBPARP1HRH2HRH1 | |
| SCHEMBL30501247 | 0.85 | DDB1 (0.41) | DDB1CRBNPOLBPARP1TNKS | |
| SCHEMBL23134720 | 0.82 | DDB1 (0.44) | DDB1CRBNPARP1TNKSMAPT | |
| SCHEMBL25935493 | 0.80 | DDB1 (0.46) | DDB1CRBNPOLBPARP1TNKS | |
| SCHEMBL29013153 | 0.78 | DDB1 (0.43) | DDB1CRBNPOLBPARP1TNKS | |
| SCHEMBL31447872 | 0.78 | DDB1 (0.45) | DDB1CRBNPARP1DRD2ALDH1A1 | |
| SCHEMBL23173222 | 0.77 | CRBN (0.52) | DDB1CRBNPARP1TNKSDRD2 | |
| SCHEMBL30135897 | 0.77 | DDB1 (0.43) | DDB1CRBNHRH2HRH1TNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4157850-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | Uppthera, Inc. (KR) | 2023-04-05 | — | — | EP | disclosed |
| WO-2023017446-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |
| WO-2023018236-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |