Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 10/20 | 0.40 |
| ▸ | CYP8B1 | Q9UNU6 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 2/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | NPY2R | P49146 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25034787 | 1.00 | FFAR4 (0.40) | FFAR4CYP8B1GRM5RORCCHRM2 | |
| SCHEMBL25819461 | 0.93 | FFAR4 (0.42) | FFAR4CYP8B1RORCCHRM2CHRM5 | |
| SCHEMBL30475467 | 0.85 | FFAR4 (0.39) | FFAR4CYP8B1GRM5NPY2R | |
| SCHEMBL25034789 | 0.85 | FFAR4 (0.39) | FFAR4CYP8B1GRM5NPY2R | |
| SCHEMBL25419978 | 0.83 | FFAR4 (0.43) | FFAR4GRM5NPY2RCHRM4 | |
| SCHEMBL29013177 | 0.83 | FFAR4 (0.47) | FFAR4GRM5NPY2RCHRM4 | |
| SCHEMBL27225001 | 0.82 | MAPT (0.42) | FFAR4GRM5CHRM2CHRM5CHRM1 | |
| SCHEMBL25029419 | 0.82 | FFAR4 (0.46) | FFAR4GRM5NPY2RCHRM4 | |
| SCHEMBL30136082 | 0.82 | LTA4H (0.41) | FFAR4GRM5CNR1 | |
| SCHEMBL25938922 | 0.82 | LTA4H (0.41) | FFAR4GRM5CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116322700-B | Novel PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2024-08-20 | — | — | CN | disclosed |
| CN-116322700-A | Novel PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2023-06-23 | — | — | CN | disclosed |
| EP-4157849-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | Uppthera, Inc. (KR) | 2023-04-05 | — | — | EP | disclosed |
| WO-2023018238-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |
| WO-2023017446-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |