Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 16/20 | 0.55 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.55 |
| ▸ | CCNC | P24863 | 1/20 | 0.49 |
| ▸ | CDK8 | P49336 | 1/20 | 0.49 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.49 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.49 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.49 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.49 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 2/20 | 0.48 |
| ▸ | AR | P10275 | 4/20 | 0.47 |
| ▸ | HPGDS | O60760 | 2/20 | 0.46 |
| ▸ | ITK | Q08881 | 3/20 | 0.46 |
| ▸ | IL2 | P60568 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30135995 | 0.90 | CRBN (0.56) | CRBNDDB1IRAK1IRAK4IRAK3 | |
| SCHEMBL22291403 | 0.86 | CRBN (0.57) | CRBNDDB1CCNCCDK8IRAK1 | |
| SCHEMBL29648407 | 0.86 | CRBN (0.57) | CRBNDDB1CCNCCDK8IRAK1 | |
| SCHEMBL31620804 | 0.86 | CRBN (0.57) | CRBNDDB1CCNCCDK8IRAK1 | |
| SCHEMBL24501945 | 0.86 | CRBN (0.57) | CRBNDDB1CCNCCDK8IRAK1 | |
| SCHEMBL20442456 | 0.86 | CRBN (0.56) | CRBNDDB1CCNCCDK8IRAK1 | |
| SCHEMBL22645391 | 0.85 | CRBN (0.55) | CRBNDDB1CCNCCDK8IRAK1 | |
| SCHEMBL22291243 | 0.85 | CRBN (0.68) | CRBNDDB1CCNCCDK8IRAK1 | |
| SCHEMBL30741730 | 0.85 | CRBN (0.68) | CRBNDDB1CCNCCDK8IRAK1 | |
| SCHEMBL30741751 | 0.84 | CRBN (0.56) | CRBNDDB1CCNCCDK8IRAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250114460-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2025-04-10 | — | — | US | disclosed |
| EP-4384520-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | Uppthera, Inc. (KR) | 2024-06-19 | — | — | EP | disclosed |
| WO-2023017442-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |
| WO-2023017446-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250114460-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | PLK1, BUB1B, BUB1 | CRBN 2136/4885DDB1 132/4885CCNC 868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.