SCHEMBL30136795

SCHEMBL30136795

CCOC(=O)c1oc2ccc(F)cc2c1C

nearest known ligand 0.62

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.62
CYP1A2 P05177 1/20 0.62
CYP3A4 P08684 1/20 0.62
CYP2C9 P11712 1/20 0.62
CYP2C19 P33261 1/20 0.62
NPSR1 Q6W5P4 1/20 0.62
L3MBTL1 Q9Y468 1/20 0.62
HIF1A Q16665 8/20 0.56
RAB9A P51151 3/20 0.56
PARG Q86W56 2/20 0.56
USP2 O75604 1/20 0.55
KDM4E B2RXH2 4/20 0.55
AHR P35869 1/20 0.55
NPC1 O15118 2/20 0.54
RXFP1 Q9HBX9 1/20 0.54
TSHR P16473 1/20 0.53
ALDH1A1 P00352 2/20 0.52
SMN1; SMN2 Q16637 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20893375 1.00 MAPT (0.62) MAPTCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL2493208 0.89 KDM4E (0.67) MAPTCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL20893409 0.89 KDM4E (0.52) MAPTCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL29224907 0.86 PLK1 (0.53) MAPTCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL19661983 0.85 KCNH2 (0.66) MAPTCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL724096 0.85 MAPT (0.64) MAPTCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL1474090 0.84 MEN1 (0.60) MAPTCYP1A2CYP2C9CYP2C19HIF1A
SCHEMBL16732898 0.83 KDM4E (0.62) MAPTL3MBTL1HIF1ARAB9APARG
SCHEMBL788918 0.83 KCNH2 (0.67) MAPTNPSR1HIF1ARAB9APARG
SCHEMBL9378819 0.83 KDM4E (0.69) MAPTHIF1ARAB9APARGUSP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4334298-A1 UREA DERIVATIVES WHICH CAN BE USED TO TREAT CANCER Scorpion Therapeutics, Inc. (US) 2024-03-13 EP disclosed
WO-2022265993-A1 UREA DERIVATIVES WHICH CAN BE USED TO TREAT CANCER SCORPION THERAPEUTICS, INC. (US) 2022-12-22 WO disclosed