Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 5/20 | 0.51 |
| ▸ | AHCY | P23526 | 10/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.44 |
| ▸ | SLC28A1 | O00337 | 2/20 | 0.44 |
| ▸ | SLC28A2 | O43868 | 2/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.44 |
| ▸ | GAPDH | P04406 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | STAT6 | P42226 | 1/20 | 0.44 |
| ▸ | PI4KA | P42356 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.44 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.44 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.44 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19859704 | 1.00 | ADORA2A (0.51) | ADORA2AAHCYADORA3SLC28A1SLC28A2 | |
| SCHEMBL25750428 | 0.92 | ADORA2A (0.51) | ADORA2AAHCYADORA3PI4KAPI4K2B | |
| SCHEMBL21078466 | 0.87 | AHCY (0.43) | ADORA2AAHCYADORA3 | |
| SCHEMBL21078589 | 0.86 | NT5E (0.48) | ADORA2AAHCYADORA3ADORA2BADORA1 | |
| SCHEMBL31228218 | 0.86 | NT5E (0.48) | ADORA2AAHCYADORA3ADORA2BADORA1 | |
| SCHEMBL16368187 | 0.86 | ADORA2A (0.49) | ADORA2AAHCYADORA3SLC28A1SLC28A2 | |
| SCHEMBL29722700 | 0.86 | ADORA2A (0.49) | ADORA2AAHCYADORA3SLC28A1SLC28A2 | |
| SCHEMBL29722780 | 0.86 | ADORA2A (0.56) | ADORA2AAHCYADORA3SLC28A1SLC28A2 | |
| SCHEMBL16368190 | 0.86 | ADORA2A (0.56) | ADORA2AAHCYADORA3SLC28A1SLC28A2 | |
| SCHEMBL19859805 | 0.84 | ADORA2A (0.62) | ADORA2AAHCYADORA3SLC28A1SLC28A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115916217-A | Alkynyl nucleoside analogs for the treatment of hepatitis E | 杨森制药公司 | 2023-04-04 | — | — | CN | disclosed |
| EP-4138850-A1 | ALKYNYL NUCLEOSIDE ANALOGS FOR TREATMENT OF HEPATITIS E | Janssen Pharmaceuticals, Inc. (US) | 2023-03-01 | — | — | EP | disclosed |
| WO-2021209425-A9 | ALKYNYL NUCLEOSIDE ANALOGS FOR TREATMENT OF HEPATITIS E | Janssen Pharmaceuticals, Inc. (US) | 2022-12-22 | — | — | WO | disclosed |