SCHEMBL30140109

SCHEMBL30140109

CC(C)(C)OC(=O)N1CC[C@H](Oc2nc3c(Nc4ccc(OCC5CC5)c(F)c4F)ncnc3cc2F)C1

nearest known ligand 0.53

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 3/20 0.53
PIK3CD O00329 13/20 0.47
PIK3CA P42336 2/20 0.47
PIK3CB P42338 2/20 0.47
PIK3CG P48736 2/20 0.47
EGFR P00533 4/20 0.46
KDR P35968 3/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30140252 0.94 GPR119 (0.52) GPR119PIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL30140079 0.93 GPR119 (0.49) GPR119PIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL30140128 0.93 GPR119 (0.49) GPR119PIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL30140298 0.90 GPR119 (0.49) GPR119PIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL30140314 0.90 GPR119 (0.49) GPR119PIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL30140215 0.90 GPR119 (0.52) GPR119PIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL30140301 0.89 GPR119 (0.55) GPR119PIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL30140318 0.89 GPR119 (0.46) GPR119PIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL30140184 0.89 GPR119 (0.55) GPR119PIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL30140274 0.88 EGFR (0.54) EGFRKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022266426-A1 6-(HETEROCYCLOALKYL-OXY)-QUINAZOLINE DERIVATIVES AND USES THEREOF BLACK DIAMOND THERAPEUTICS, INC. (US) 2022-12-22 WO disclosed