Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.41 |
| ▸ | KDR | P35968 | 4/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | FLT1 | P17948 | 2/20 | 0.38 |
| ▸ | FLT4 | P35916 | 2/20 | 0.38 |
| ▸ | EPHA2 | P29317 | 4/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.35 |
| ▸ | EIF4E | P06730 | 1/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30140210 | 1.00 | EGFR (0.42) | EGFRMKNK2KDRFGFR1FLT1 | |
| SCHEMBL30140412 | 0.92 | KDR (0.43) | EGFRMKNK2KDRFGFR1FLT1 | |
| SCHEMBL30140295 | 0.88 | EGFR (0.41) | EGFRMKNK2KDRFGFR1FLT1 | |
| SCHEMBL30140076 | 0.87 | EPHA2 (0.42) | EGFRMKNK2KDRFGFR1FLT1 | |
| SCHEMBL30140218 | 0.87 | EPHA2 (0.42) | EGFRMKNK2KDRFGFR1FLT1 | |
| SCHEMBL30140353 | 0.85 | KDR (0.44) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL30140086 | 0.83 | EGFR (0.35) | EGFRMKNK2KDRFGFR1FLT1 | |
| SCHEMBL30140346 | 0.81 | EGFR (0.46) | EGFRMKNK2KDRFGFR1FLT1 | |
| SCHEMBL30140131 | 0.81 | EGFR (0.46) | EGFRMKNK2KDRFGFR1FLT1 | |
| SCHEMBL30140107 | 0.81 | EGFR (0.39) | EGFRKDRFGFR1FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022266426-A1 | 6-(HETEROCYCLOALKYL-OXY)-QUINAZOLINE DERIVATIVES AND USES THEREOF | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2022-12-22 | — | — | WO | disclosed |