Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.43 |
| ▸ | EGFR | P00533 | 12/20 | 0.43 |
| ▸ | FLT1 | P17948 | 10/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.43 |
| ▸ | FLT4 | P35916 | 9/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
| ▸ | EPHA2 | P29317 | 6/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.36 |
| ▸ | TEK | Q02763 | 2/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.36 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | CIT | O14578 | 1/20 | 0.36 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | STK10 | O94804 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30140353 | 0.93 | KDR (0.44) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL30140210 | 0.92 | EGFR (0.42) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL30140239 | 0.92 | EGFR (0.42) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL30140076 | 0.88 | EPHA2 (0.42) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL30140218 | 0.88 | EPHA2 (0.42) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL30140086 | 0.87 | EGFR (0.35) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL30140107 | 0.87 | EGFR (0.39) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL30140339 | 0.86 | EGFR (0.41) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL23538163 | 0.83 | EGFR (0.45) | KDREGFRFLT1RETEPHA2 | |
| SCHEMBL23538160 | 0.83 | EGFR (0.45) | KDREGFRFLT1RETEPHA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022266426-A1 | 6-(HETEROCYCLOALKYL-OXY)-QUINAZOLINE DERIVATIVES AND USES THEREOF | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2022-12-22 | — | — | WO | disclosed |