Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 6/20 | 0.36 |
| ▸ | RBP4 | P02753 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21747035 | 1.00 | KLKB1 (0.36) | KLKB1RBP4DYRK1AHCRTR1HCRTR2 | |
| SCHEMBL21747131 | 0.84 | KLKB1 (0.36) | KLKB1 | |
| SCHEMBL30140673 | 0.84 | KLKB1 (0.36) | KLKB1 | |
| SCHEMBL23469510 | 0.78 | KLKB1 (0.41) | KLKB1RBP4DYRK1AHCRTR1HCRTR2 | |
| SCHEMBL20541008 | 0.78 | NR1H2 (0.45) | KLKB1RBP4DYRK1AHCRTR1HCRTR2 | |
| SCHEMBL18794997 | 0.78 | HDAC3 (0.33) | RBP4 | |
| SCHEMBL21746998 | 0.78 | KLKB1 (0.39) | KLKB1 | |
| SCHEMBL21736743 | 0.69 | KLKB1 (0.49) | KLKB1RBP4HCRTR1HCRTR2 | |
| SCHEMBL21736872 | 0.66 | KLKB1 (0.47) | KLKB1RBP4HCRTR1HCRTR2 | |
| SCHEMBL22166243 | 0.66 | KLKB1 (0.59) | KLKB1RBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113039181-B | Heteroaromatic carboxamide derivatives as inhibitors of plasma kallikrein | 勃林格殷格翰国际有限公司 | 2024-08-13 | — | — | CN | disclosed |
| CN-110546146-B | Heteroaryl carboxamide derivatives as plasma kallikrein inhibitors | 勃林格殷格翰国际有限公司 | 2023-02-21 | — | — | CN | disclosed |