Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 1.00 |
| ▸ | GAA | P10253 | 2/20 | 0.73 |
| ▸ | MAPT | P10636 | 2/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.57 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | ELANE | P08246 | 1/20 | 0.51 |
| ▸ | AR | P10275 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | TDO2 | P48775 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CCR9 | P51686 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22668259 | 0.87 | HTT (0.77) | HTTGAAMAPTHSD17B10MAPK1 | |
| SCHEMBL18589024 | 0.84 | HTT (0.73) | HTTGAAMAPTHSD17B10MAPK1 | |
| SCHEMBL4122353 | 0.82 | HTT (0.70) | HTTGAAMAPTHSD17B10MAPK1 | |
| SCHEMBL441164 | 0.82 | HTT (0.70) | HTTGAAMAPTHSD17B10MAPK1 | |
| SCHEMBL16862943 | 0.82 | HTT (0.69) | HTTGAAMAPTHSD17B10MAPK1 | |
| SCHEMBL16862998 | 0.81 | HTT (0.67) | HTTGAAMAPTHSD17B10MAPK1 | |
| SCHEMBL29644725 | 0.80 | HTT (0.67) | HTTGAAMAPTHSD17B10MAPK1 | |
| SCHEMBL28603975 | 0.80 | HTT (0.67) | HTTGAAMAPTHSD17B10MAPK1 | |
| SCHEMBL11619942 | 0.78 | KDM4E (0.70) | HTTGAAKDM4EALDH1A1SMN1; SMN2 | |
| N-Phenyl-Phthalimide SCHEMBL29819622 | 0.77 | KMT2A (0.68) | HTTGAAMAPTHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110546146-B | Heteroaryl carboxamide derivatives as plasma kallikrein inhibitors | 勃林格殷格翰国际有限公司 | 2023-02-21 | — | — | CN | disclosed |