Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ELANE | P08246 | 1/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL441164 | 0.83 | HTT (0.70) | HTTMAPTGAAHSD17B10MAPK1 | |
| SCHEMBL30140692 | 0.82 | HTT (1.00) | HTTMAPTGAAHSD17B10MAPK1 | |
| SCHEMBL18589024 | 0.82 | HTT (0.73) | HTTMAPTGAAHSD17B10MAPK1 | |
| SCHEMBL16862998 | 0.81 | HTT (0.67) | HTTMAPTGAAHSD17B10MAPK1 | |
| SCHEMBL22668259 | 0.81 | HTT (0.77) | HTTMAPTGAAHSD17B10MAPK1 | |
| SCHEMBL4112740 | 0.79 | HTT (0.45) | HTTMAPTGAAHSD17B10MAPK1 | |
| SCHEMBL4112737 | 0.79 | HTT (0.45) | HTTMAPTGAAHSD17B10MAPK1 | |
| SCHEMBL20062884 | 0.76 | CYP2A6 (0.50) | HTTMAPTGAAHSD17B10MAPK1 | |
| SCHEMBL16863005 | 0.75 | HTT (0.54) | HTTMAPTGAAHSD17B10MAPK1 | |
| SCHEMBL4130006 | 0.74 | CYP11B2 (0.51) | HTTMAPTGAAHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1566378-B1 | ISOINDOLINE DERIVATIVE | MARUISHI PHARMA (JP) | 2012-08-15 | — | — | EP | disclosed |
| US-20090170835-A1 | ISOINDOLINE DERIVATIVES | MARUISHI PHARMACEUTICAL CO., LTD. | 2009-07-02 | — | — | US | disclosed |
| US-7521451-B2 | Isoindoline derivative | MARUISHI PHARMACEUTICAL CO., LTD. (JP) | 2009-04-21 | — | — | US | disclosed |
| US-20060052392-A1 | e.g. 5,6-dimethyl-3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione;intravenous, water-soluble compounds useful for manufacturing an anasthetic, sedative agents; side effect reduction | MARUISHI PHARMACEUTICAL CO., LTD | 2006-03-09 | — | — | US | disclosed |
| EP-1566378-A1 | ISOINDOLINE DERIVATIVE | Maruishi Pharmaceutical Co., Ltd. (JP) | 2005-08-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060052392-A1 | e.g. 5,6-dimethyl-3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione;intravenous, water-soluble compounds useful for manufacturing an anasthetic, sedative agents; side effect reduction | CYP3A5, OPRD1, CYP3A7 | HTT 1922/4885MAPT 2980/4885GAA 2799/4885 |
| US-20090170835-A1 | ISOINDOLINE DERIVATIVES | OPRD1, OPRK1, OPRL1 | HTT 3641/4885MAPT 1879/4885GAA 4640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.