Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 3/20 | 0.36 |
| ▸ | FLT1 | P17948 | 5/20 | 0.36 |
| ▸ | KDR | P35968 | 5/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | IL1B | P01584 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24906428 | 1.00 | AKR1C3 (0.40) | AKR1C3AKR1C2KDM1ABACE1FLT1 | |
| SCHEMBL24758201 | 0.95 | AKR1C3 (0.37) | AKR1C3AKR1C2KDM1ABACE1FLT1 | |
| SCHEMBL30107024 | 0.95 | AKR1C3 (0.37) | AKR1C3AKR1C2KDM1ABACE1FLT1 | |
| SCHEMBL24906446 | 0.93 | AKR1C3 (0.40) | AKR1C3AKR1C2KDM1ABACE1FLT1 | |
| SCHEMBL24758407 | 0.90 | AKR1C3 (0.41) | AKR1C3AKR1C2FLT1KDRHDAC1 | |
| SCHEMBL30141553 | 0.90 | AKR1C3 (0.41) | AKR1C3AKR1C2FLT1KDRHDAC1 | |
| SCHEMBL24758976 | 0.87 | AKR1C3 (0.40) | AKR1C3AKR1C2KDM1AFLT1KDR | |
| SCHEMBL24906358 | 0.86 | AKR1C3 (0.39) | AKR1C3AKR1C2BACE1SCN10A | |
| SCHEMBL24757793 | 0.85 | AKR1C3 (0.46) | AKR1C3AKR1C2KDM1ARIPK1SCN10A | |
| SCHEMBL24757356 | 0.85 | SCN10A (0.48) | AKR1C3AKR1C2SCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4355733-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2024-04-24 | — | — | EP | claimed |
| WO-2022263498-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2022-12-22 | — | — | WO | claimed |
| EP-4355733-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2024-04-24 | — | — | EP | disclosed |
| WO-2022263498-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2022-12-22 | — | — | WO | disclosed |