Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 5/20 | 0.38 |
| ▸ | KDR | P35968 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24758407 | 1.00 | AKR1C3 (0.41) | AKR1C3AKR1C2FLT1KDRLMNA | |
| SCHEMBL24906428 | 0.90 | AKR1C3 (0.40) | AKR1C3AKR1C2FLT1KDRHDAC1 | |
| SCHEMBL30141388 | 0.90 | AKR1C3 (0.40) | AKR1C3AKR1C2FLT1KDRHDAC1 | |
| SCHEMBL30107024 | 0.87 | AKR1C3 (0.37) | AKR1C3AKR1C2FLT1KDRHTR2A | |
| SCHEMBL24758201 | 0.87 | AKR1C3 (0.37) | AKR1C3AKR1C2FLT1KDRHTR2A | |
| SCHEMBL24906506 | 0.85 | AR (0.45) | AKR1C3AKR1C2GRM4 | |
| SCHEMBL24906446 | 0.83 | AKR1C3 (0.40) | AKR1C3AKR1C2FLT1KDRHDAC1 | |
| SCHEMBL24757791 | 0.80 | AKR1C3 (0.45) | AKR1C3AKR1C2FLT1KDRCNR2 | |
| SCHEMBL24758152 | 0.80 | SCN10A (0.50) | AKR1C3AKR1C2 | |
| SCHEMBL24906272 | 0.79 | MEN1 (0.52) | AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4355733-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2024-04-24 | — | — | EP | disclosed |
| WO-2022263498-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2022-12-22 | — | — | WO | disclosed |