Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CRACR2A | Q9BSW2 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 4/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24758160 | 1.00 | JAK2 (0.38) | JAK2JAK1JAK3CASP6CNR2 | |
| SCHEMBL24758163 | 0.90 | ALDH1A1 (0.41) | CASP6CNR2ALDH1A1MEN1KMT2A | |
| SCHEMBL24758415 | 0.87 | SCN10A (0.40) | CNR2ALDH1A1POLBGRM4 | |
| SCHEMBL30141451 | 0.87 | SCN10A (0.40) | CNR2ALDH1A1POLBGRM4 | |
| SCHEMBL24757318 | 0.87 | SCN10A (0.40) | CNR2ALDH1A1POLBGRM4 | |
| SCHEMBL24757336 | 0.83 | AKR1C3 (0.37) | CRACR2A | |
| SCHEMBL24906276 | 0.83 | SCN10A (0.42) | ALDH1A1MEN1KMT2A | |
| SCHEMBL30141552 | 0.81 | PDE8B (0.43) | ALDH1A1GAAKMT2AKDM4EHPGD | |
| SCHEMBL24906447 | 0.80 | SCN10A (0.43) | CNR2 | |
| SCHEMBL24906475 | 0.80 | SCN10A (0.43) | CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4355733-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2024-04-24 | — | — | EP | disclosed |
| WO-2022263498-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2022-12-22 | — | — | WO | disclosed |