⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25167212 | 1.00 | — | — | |
| SCHEMBL25167213 | 1.00 | — | — | |
| SCHEMBL25461869 | 0.88 | DGAT1 (0.30) | — | |
| SCHEMBL25168256 | 0.87 | — | — | |
| SCHEMBL31539631 | 0.87 | — | — | |
| SCHEMBL25167215 | 0.85 | — | — | |
| SCHEMBL25167214 | 0.85 | — | — | |
| SCHEMBL25171407 | 0.83 | — | — | |
| SCHEMBL30758103 | 0.83 | — | — | |
| SCHEMBL30758105 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4563579-A1 | MACROCYCLIC EGFR INHIBITOR, AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2025-06-04 | — | — | EP | disclosed |
| WO-2024022286-A1 | MACROCYCLIC EGFR INHIBITOR, AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | 上海和誉生物医药科技有限公司 | 2024-02-01 | — | — | WO | disclosed |
| EP-4107160-A1 | MACROCYCLIC COMPOUNDS AND USES THEREOF | Theseus Pharmaceuticals, Inc. (US) | 2022-12-28 | — | — | EP | disclosed |