Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 3/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.47 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | PI4KA | P42356 | 1/20 | 0.47 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.44 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.44 |
| ▸ | DHFR | P00374 | 6/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15060234 | 0.74 | LRRK2 (0.49) | BMPR1AACVRL1ACVR1DHFRLRRK2 | |
| SCHEMBL18781466 | 0.73 | FGFR1 (0.50) | PIK3CDPIK3CAPIK3CGPI4KBPIK3CB | |
| SCHEMBL19668085 | 0.72 | PIK3CD (0.47) | PIK3CDPIK3CAPIK3CGPI4KBPIK3CB | |
| SCHEMBL19668074 | 0.72 | PIK3CD (0.47) | PIK3CDPIK3CAPIK3CGPI4KBPIK3CB | |
| SCHEMBL19668091 | 0.72 | PIK3CA (0.47) | PIK3CDPIK3CAPIK3CGPI4KBPIK3CB | |
| SCHEMBL18781279 | 0.71 | PIK3CD (0.46) | PIK3CDPIK3CAPIK3CGPI4KBPIK3CB | |
| SCHEMBL16339646 | 0.71 | PIK3CD (0.49) | PIK3CDPIK3CAPIK3CGPI4KBPIK3CB | |
| SCHEMBL18985660 | 0.70 | PIK3CD (0.46) | PIK3CDPIK3CAPIK3CGPI4KBPIK3CB | |
| SCHEMBL18985753 | 0.70 | PIK3CD (0.46) | PIK3CDPIK3CAPIK3CGPI4KBPIK3CB | |
| SCHEMBL30819778 | 0.70 | ACVRL1 (0.54) | BMPR1AACVRL1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115650958-B | 2-Aminopyrimidine compound, preparation method, application and pharmaceutical composition thereof | 中国药科大学 | 2024-05-17 | — | — | CN | disclosed |
| CN-115650958-A | 2-aminopyrimidine compound and preparation method, application and pharmaceutical composition thereof | 中国药科大学 | 2023-01-31 | — | — | CN | disclosed |