Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 10/20 | 0.60 |
| ▸ | ESR1 | P03372 | 2/20 | 0.60 |
| ▸ | IKZF2 | Q9UKS7 | 8/20 | 0.58 |
| ▸ | WIZ | O95785 | 1/20 | 0.49 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27194530 | 1.00 | CRBN (0.60) | CRBNESR1IKZF2WIZIKZF1 | |
| Hydrochloric Acid SCHEMBL27194374 | 0.99 | CRBN (0.60) | CRBNESR1IKZF2WIZIKZF1 | |
| Hydrochloric Acid SCHEMBL30828145 | 0.99 | CRBN (0.60) | CRBNESR1IKZF2WIZIKZF1 | |
| SCHEMBL31129474 | 0.95 | CRBN (0.62) | CRBNESR1IKZF2WIZIKZF1 | |
| SCHEMBL27310070 | 0.94 | CRBN (0.59) | CRBNESR1IKZF2WIZ | |
| SCHEMBL31129737 | 0.93 | CRBN (0.58) | CRBNESR1IKZF2WIZIKZF1 | |
| SCHEMBL27308323 | 0.93 | CRBN (0.61) | CRBNESR1IKZF2WIZIKZF1 | |
| SCHEMBL31134571 | 0.93 | CRBN (0.55) | CRBNESR1IKZF2 | |
| SCHEMBL24735305 | 0.93 | CRBN (0.60) | CRBNESR1IKZF2WIZIKZF1 | |
| SCHEMBL22600233 | 0.93 | CRBN (0.60) | CRBNESR1IKZF2WIZIKZF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023023537-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF BRUTON'S TYROSINE KINASE | ENDOTARGET INC. (US) | 2023-02-23 | — | — | WO | claimed |
| EP-4655073-A2 | CEREBLON-BASED KRAS DEGRADING PROTACS ANS USES RELATED THERETO | Arvinas Operations, Inc. (US) | 2025-12-03 | — | — | EP | disclosed |
| EP-4584258-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2025-07-16 | — | — | EP | disclosed |
| WO-2024159164-A2 | CEREBLON-BASED KRAS DEGRADING PROTACS ANS USES RELATED THERETO | ARVINAS OPERATIONS, INC. (US) | 2024-08-02 | — | — | WO | disclosed |
| WO-2024054591-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |